METHOTREXATE FOR SYSTEMIC LUPUS-ERYTHEMATOSUS - A RETROSPECTIVE ANALYSIS OF 17 UNSELECTED CASES

被引：0

作者：

WILKE, WS ^{[1
]}

KRALL, PL ^{[1
]}

SCHEETZ, RJ ^{[1
]}

BABIAK, T ^{[1
]}

DANAO, T ^{[1
]}

MAZANEC, DJ ^{[1
]}

SEGAL, AM ^{[1
]}

CLOUGH, JD ^{[1
]}

机构：

[1] CLEVELAND CLIN FDN,DEPT RHEUMAT & IMMUNOL DIS,CLEVELAND,OH 44195

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 1991年 / 9卷 / 06期

关键词：

METHOTREXATE; SYSTEMIC LUPUS ERYTHEMATOSUS; THERAPY; METHOTREXATE TOXICITY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a retrospective study of 17 patients with systemic lupus erythematosus who were treated with oral methotrexate given as a mean weekly dose of 8.47 +/- 1.72 mg. Methotrexate treatment resulted in symptomatic improvement in 57% of patients and allowed the reduction of the mean daily dose of prednisone from 16.66 mg initially to 8.99 mg at one year follow-up. Twelve of 17 patients (70.6%) experienced at least one episode of toxicity. Factors which might be associated with toxicity are analyzed. Because of its potential as a corticosteroid-sparing agent, controlled studies of methotrexate for the treatment of systemic lupus erythematosus are indicated.

引用

页码：581 / 587

页数：7

共 50 条

[31] SYSTEMIC LUPUS-ERYTHEMATOSUS
KOFFLER, D
SCIENTIFIC AMERICAN, 1980, 243 (01) : 52 - 61
[32] SYSTEMIC LUPUS-ERYTHEMATOSUS
BRESCHI, L
MITI, L
GIULIONI, S
CIVERCHIA, D
MINERVA MEDICA, 1978, 69 (57) : 3891 - 3900
[33] SYSTEMIC LUPUS-ERYTHEMATOSUS
CHAHADE, WH
CUNHA, KDBC
DOURADOR, EB
PACHECO, JP
REVISTA BRASILEIRA DE MEDICINA, 1990, 47 : 105 - &
[34] SYSTEMIC LUPUS-ERYTHEMATOSUS
LEBACQ, EG
LOUVAIN MEDICAL, 1977, 96 (09): : 471 - 481
[35] SYSTEMIC LUPUS-ERYTHEMATOSUS
CHRISTIAN, CL
CLINICAL AND EXPERIMENTAL DIALYSIS AND APHERESIS, 1981, 5 (1-2): : 93 - 99
[36] SYSTEMIC LUPUS-ERYTHEMATOSUS
BLETRY, O
REVUE DE MEDECINE, 1977, 18 (25): : 1238 - &
[37] SYSTEMIC LUPUS-ERYTHEMATOSUS
HUGHES, GRV
POSTGRADUATE MEDICAL JOURNAL, 1988, 64 (753) : 517 - 521
[38] SYSTEMIC LUPUS-ERYTHEMATOSUS
MITCHELL, E
KELLY, AMT
BRITISH JOURNAL OF DERMATOLOGY, 1984, 111 : 97 - 98
[39] SYSTEMIC LUPUS-ERYTHEMATOSUS
KUSSMAUL, C
BURDASH, N
SIENKNECHT, CW
AMERICAN JOURNAL OF MEDICAL TECHNOLOGY, 1978, 44 (08): : 814 - 818
[40] SYSTEMIC LUPUS-ERYTHEMATOSUS
SCHRODER, JO
EULER, HH
INTERNIST, 1993, 34 (04): : 351 - 361

← 1 2 3 4 5 →