Synthesis, antibacterial and antifungal activities of some newer cephlosporin derivatives

被引：0

作者：

Sharma, Neeraj ^{[1
]}

Aggarwal, T. P. ^{[1
]}

Bhati, Sudhir Kumar

Kumar, Ashok ^{[2
]}

机构：

[1] KGK PG Coll, Dept Chem, Moradabad, India

[2] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 25004, Uttar Pradesh, India

来源：

ORIENTAL JOURNAL OF CHEMISTRY | 2010年 / 26卷 / 02期

关键词：

Cephlosporin derivatives; Antibacterial and Antimicrobial activities;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

7-(D-5-Amino-5-carboxy-valeramido)-3-(acetylhydrazido)-8-oxo-5-thio-1-azabicyclo [4,2,0]-oct-2-ene-2-carboxylic acid (1). 7-(D-5-Amino-5-carboxy-valeramido)-3-(substitutedarylacetylhydrazido)-8-oxo-5-thio-1-azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid.(2-5). 7-(D-5-Amino-5-carboxyvaleramido)-3-(2'-substituted aryl-3'-chloro-4'-oxo-azetidin-1'-yl)-acetylamino]-8-oxo-5-thio-1azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid (6-9). 7-(D-5-Amino-5-carboxy-valeramido)-3-[(2'substitutedaryl-4'-oxo-thiazolidin-3'-yl)-acetyl amino]-8-oxo-5-thio-1-azabicyclo [4, 2, 0]-oct-2-ene-2-carboxylic acid.(10-13) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 11 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole.

引用

页码：537 / 545

页数：9

共 50 条

[21] Synthesis, characterization, antibacterial, antifungal, and immunomodulating activities of gatifloxacin derivatives
Najma Sultana
Asia Naz
Bushra Khan
M. Saeed Arayne
M. Ahmed Mesaik
Medicinal Chemistry Research, 2010, 19 : 1210 - 1221
[22] SYNTHESIS AND ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF THIOUREA DERIVATIVES OF THE ALKALOID ANABASINE
Kulakov, I. V.
Nurkenov, O. A.
Akhmetova, S. B.
Seidakhmetova, R. B.
Zhambekov, Z. M.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2011, 45 (01) : 15 - 18
[23] Studies on synthesis, characterization, antifungal and antibacterial activities of organosilicon derivatives
Department of Chemistry, University of Rajasthan, Jaipur, India
J. Chem. Pharm. Res., 10 (260-265):
[24] Synthesis, characterization, antibacterial, antifungal, and immunomodulating activities of gatifloxacin derivatives
Sultana, Najma
Naz, Asia
Khan, Bushra
Arayne, M. Saeed
Mesaik, M. Ahmed
MEDICINAL CHEMISTRY RESEARCH, 2010, 19 (09) : 1210 - 1221
[25] Synthesis, Characterization, Antifungal, Antibacterial, and Antitumor Activities of Some Tris(pentafluorophenyl)arsenic(V) Derivatives
Mishra, Rahul
Singhal, Kiran
Ranjan, Ashok
Saxena, A. K.
Raj, Prem
HETEROATOM CHEMISTRY, 2010, 21 (03) : 181 - 187
[26] Antibacterial, antifungal and antimycobacterial activities of some pyrazoline, hydrazone and chalcone derivatives
Evranos-Aksoz, Begum
Onurdag, Fatma Kaynak
Ozgacar, Selda Ozgen
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2015, 70 (7-8): : 183 - 189
[27] SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF SOME NEW TRIAZOLYLACETOPHENONE DERIVATIVES
ERTAN, R
AYHAN, G
YULUG, N
ROLLAND, Y
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1995, 45-1 (05): : 620 - 623
[28] Synthesis and Antifungal Activities of Some Novel Pyrimidine Derivatives
Sun, Li
Wu, Jie
Zhang, Lingzi
Luo, Min
Sun, Dequn
MOLECULES, 2011, 16 (07): : 5618 - 5628
[29] Synthesis, antitubercular, antibacterial and antifungal activities of some hydrazones and their spirothiazolidinones
Alagarsamy, V
Venkateshperumal, R
Sathyabhama, S
Vaishnavapriya, S
Sakkarapandi, S
Revathi, S
Kalaiselvi, R
Balamurugan, J
Sevukarajan, M
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2002, 11 (04) : 327 - 328
[30] SYNTHESIS AND EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF SOME NOVEL 1,3,4-OXADIAZOLE DERIVATIVES
Nadagouda, S. G.
Pawar, Sunil
Gadaginamath, Late G. S.
Dubey, Deepak Kumar
Hallikeri, C. S.
Joshi, S. D.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 22 (04) : 341 - 344

← 1 2 3 4 5 →