Synthesis, antibacterial and antifungal activities of some newer cephlosporin derivatives

被引：0
|
作者：
Sharma, Neeraj [1 ]
Aggarwal, T. P. [1 ]
Bhati, Sudhir Kumar
Kumar, Ashok [2 ]
机构：
[1] KGK PG Coll, Dept Chem, Moradabad, India
[2] LLRM Med Coll, Dept Pharmacol, Div Med Chem, Meerut 25004, Uttar Pradesh, India
来源：
ORIENTAL JOURNAL OF CHEMISTRY | 2010年 / 26卷 / 02期
关键词：
Cephlosporin derivatives; Antibacterial and Antimicrobial activities;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
7-(D-5-Amino-5-carboxy-valeramido)-3-(acetylhydrazido)-8-oxo-5-thio-1-azabicyclo [4,2,0]-oct-2-ene-2-carboxylic acid (1). 7-(D-5-Amino-5-carboxy-valeramido)-3-(substitutedarylacetylhydrazido)-8-oxo-5-thio-1-azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid.(2-5). 7-(D-5-Amino-5-carboxyvaleramido)-3-(2'-substituted aryl-3'-chloro-4'-oxo-azetidin-1'-yl)-acetylamino]-8-oxo-5-thio-1azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid (6-9). 7-(D-5-Amino-5-carboxy-valeramido)-3-[(2'substitutedaryl-4'-oxo-thiazolidin-3'-yl)-acetyl amino]-8-oxo-5-thio-1-azabicyclo [4, 2, 0]-oct-2-ene-2-carboxylic acid.(10-13) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 11 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole.
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页码：537 / 545
页数：9
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