CYCLOCONDENSATION OF N-(2-BROMOETHYL)PHTHALIMIDE WITH THE DIANION OF ISOBUTYRIC ACID TO A FUNCTIONALIZED 2,3-DIHYDROOXAZOLO[2,3]ISOINDOL-5(9BH)-ONE DERIVATIVE

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作者
DEKIMPE, N [1 ]
VIRAG, M [1 ]
KEPPENS, M [1 ]
SCHEINMANN, F [1 ]
STACHULSKI, AV [1 ]
机构
[1] SALFORD ULTRAFINE CHEM & RES LTD,MANCHESTER M15 6SY,LANCS,ENGLAND
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O6 [化学];
学科分类号
0703 ;
摘要
Contrary to a previous report describing that the condensation or N-(2-bromoethyl)phthalimide with the dianion of isobutyric acid affords 3-{2-[(aziridin-1-yl)carbonyl]phenyl}-2,2-dimethyl-3-oxopropanoic acid, we report that this reaction in fact leads to 2-(5-oxo-2,3,5,9b-tetrahydrooxazolo[2,3-a]isoindol-9b-yl)-2-methylpropanoic acid.
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页码:252 / 253
页数:2
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