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MONOSUBSTITUTED DERIVATIVES OF FERROCENE - FERROCENE-CONTAINING PENICILLINS AND CEPHALOSPORINS
被引:20
|作者:
SCUTARU, D
[1
]
TATARU, L
[1
]
MAZILU, I
[1
]
DIACONU, E
[1
]
LIXANDRU, T
[1
]
SIMIONESCU, C
[1
]
机构:
[1] INST POLYTECH GHEORGHE ASACHI,DEPT ORGAN CHEM,STR 23 AUGUST,11,R-6600 IASI,ROMANIA
关键词:
D O I:
10.1016/0022-328X(91)86197-X
中图分类号:
O61 [无机化学];
学科分类号:
070301 ;
081704 ;
摘要:
Six new penicillins and six new cephalosporins have been obtained through acylation (using the mixed-anhydride technique) of 6-aminopenicillanic acid and 7-aminocephalosporanic acid with S-(1-ferrocenylalkyl)thioglycolic and S-(1-ferrocenylmethyl)thioglycolic acids. The products were characterized as natrium salts, through spectroscopic analysis (IR, UV) and TLC. Their biological activity towards Gram-positive bacteria is comparable to that of amoxicillin, carbenicillin and cephalothin, while their activity towards Gram-negative bacteria was insignificant.
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页码:81 / 85
页数:5
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