MONOSUBSTITUTED DERIVATIVES OF FERROCENE - FERROCENE-CONTAINING PENICILLINS AND CEPHALOSPORINS

被引：20
|
作者：
SCUTARU, D [1 ]
TATARU, L [1 ]
MAZILU, I [1 ]
DIACONU, E [1 ]
LIXANDRU, T [1 ]
SIMIONESCU, C [1 ]
机构：
[1] INST POLYTECH GHEORGHE ASACHI,DEPT ORGAN CHEM,STR 23 AUGUST,11,R-6600 IASI,ROMANIA
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1991年 / 401卷 / 1-2期
关键词：
D O I：
10.1016/0022-328X(91)86197-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Six new penicillins and six new cephalosporins have been obtained through acylation (using the mixed-anhydride technique) of 6-aminopenicillanic acid and 7-aminocephalosporanic acid with S-(1-ferrocenylalkyl)thioglycolic and S-(1-ferrocenylmethyl)thioglycolic acids. The products were characterized as natrium salts, through spectroscopic analysis (IR, UV) and TLC. Their biological activity towards Gram-positive bacteria is comparable to that of amoxicillin, carbenicillin and cephalothin, while their activity towards Gram-negative bacteria was insignificant.
引用
收藏
页码：81 / 85
页数：5
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