TREATMENT OF DIARRHEA IN CARCINOID-SYNDROME WITH ONDANSETRON, TROPISETRON, AND CLONIDINE

被引：0
|
作者：
SCHWORER, H [1 ]
MUNKE, H [1 ]
STOCKMANN, F [1 ]
RAMADORI, G [1 ]
机构：
[1] UNIV GOTTINGEN,DEPT MED,DIV GASTROENTEROL & ENDOCRINOL,W-3400 GOTTINGEN,GERMANY
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 1995年 / 90卷 / 04期
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D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
A 69-yr-old man with known carcinoid syndrome treated with octreotide and interferon-alpha(2b) developed diarrhea, with six to eight watery to semiliquid stools per day. Diminished stool frequency and increased stool consistency were obtained by treatment with the 5-hydroxytryptamine-3 receptor antagonists ondansetron and tropisetron, Successful alleviation of the diarrhea was also observed with the alpha 2-receptor agonist clonidine, These observations indicate that these classes of drugs should be evaluated in a controlled trial in patients with carcinoid-associated diarrhea.
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页码：645 / 648
页数：4
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