THE CALCIUM LOADING OF SECRETORY GRANULES - A POSSIBLE KEY EVENT IN STIMULUS-SECRETION COUPLING

被引：71

作者：

NICAISE, G ^{[1
]}

MAGGIO, K ^{[1
]}

THIRION, S ^{[1
]}

HOROYAN, M ^{[1
]}

KEICHER, E ^{[1
]}

机构：

[1] HOP ST MARGUERITE, IMMUNOL LAB, F-13274 MARSEILLE 9, FRANCE

来源：

BIOLOGY OF THE CELL | 1992年 / 75卷 / 02期

关键词：

SECRETORY GRANULES; CALCIUM; PROTONS; CA-2+ ATPASE;

D O I：

10.1016/0248-4900(92)90128-N

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The review focuses on calcium accumulation by secretory organelles. The observation that secretory granules contain variable and often important quantities of calcium (1-200 mM of total calcium) can be interpreted as a maturation in ex. A progressive loading with calcium would be permitted by a Ca2+-transport mechanism on the granular membrane and calcium-binding molecules in the granular core. The saturation of this store by the stimulus-induced calcium transient would permit in mature (calcium-loaded) granules the ionic crisis leading to exocytosis. The inside of secretory organelles being acidic, calcium influx into the granule can be driven by calcium-proton exchange. The calcium-proton exchanger could be a Ca2+-ATPase.

引用

页码：89 / 99

页数：11

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