THE CALCIUM LOADING OF SECRETORY GRANULES - A POSSIBLE KEY EVENT IN STIMULUS-SECRETION COUPLING

被引：71
|
作者：
NICAISE, G [1 ]
MAGGIO, K [1 ]
THIRION, S [1 ]
HOROYAN, M [1 ]
KEICHER, E [1 ]
机构：
[1] HOP ST MARGUERITE, IMMUNOL LAB, F-13274 MARSEILLE 9, FRANCE
来源：
BIOLOGY OF THE CELL | 1992年 / 75卷 / 02期
关键词：
SECRETORY GRANULES; CALCIUM; PROTONS; CA-2+ ATPASE;
D O I：
10.1016/0248-4900(92)90128-N
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The review focuses on calcium accumulation by secretory organelles. The observation that secretory granules contain variable and often important quantities of calcium (1-200 mM of total calcium) can be interpreted as a maturation in ex. A progressive loading with calcium would be permitted by a Ca2+-transport mechanism on the granular membrane and calcium-binding molecules in the granular core. The saturation of this store by the stimulus-induced calcium transient would permit in mature (calcium-loaded) granules the ionic crisis leading to exocytosis. The inside of secretory organelles being acidic, calcium influx into the granule can be driven by calcium-proton exchange. The calcium-proton exchanger could be a Ca2+-ATPase.
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页码：89 / 99
页数：11
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