SYNTHESIS OF 9-[C-11]METHYLAMINO-1,2,3,4-TETRAHYDROACRIDINE, A POTENT ACETYLCHOLINE ESTERASE INHIBITOR

被引：0

作者：

BONNOT, S ^{[1
]}

PRENANT, C ^{[1
]}

CROUZEL, C ^{[1
]}

机构：

[1] CEA,DRIPP,SERV HOSP FREDERIC JOLIOT,F-91406 ORSAY,FRANCE

来源：

APPLIED RADIATION AND ISOTOPES | 1991年 / 42卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method is described by which 3.7 GBq (100 mCi) of a derivative of tetrahydroaminoacridine (THA): N-[C-11]methyl THA may be obtained from about 55.5 GBq (1.5 Ci) of [C-11]CO2. THA is methylated with [C-11]methyl iodide after deprotonation by sodium hydride in dimethyl sulphoxide at 100-degrees-C. The specific activity averages 35 GBq/mu-mol (950 mCi/mu-mol) at the end of synthesis (total time of synthesis: 45 min from EOB).

引用

页码：690 / 691

页数：2

共 50 条

[31] THEORETICAL-STUDY OF SOME HETEROCYCLIC AMINES WITH APPLICATIONS TO THE CHEMISTRY OF 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE
POP, E
BREWSTER, ME
KAMINSKI, JJ
BODOR, N
INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, 1989, 35 (02) : 315 - 324
[32] SYNTHESIS AND X-RAY STRUCTURAL INVESTIGATION OF 6-CHLORO-10-PHENYL-1,2,3,4-TETRAHYDROACRIDINE
PONOMAREV, II
SHISHKIN, OV
LINDEMAN, SV
VOLKOVA, YA
RUSSIAN CHEMICAL BULLETIN, 1994, 43 (08) : 1390 - 1391
[33] INHIBITION OF RAT-BRAIN HISTAMINE-N-METHYLTRANSFERASE BY 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (THA)
CUMMING, P
REINER, PB
VINCENT, SR
BIOCHEMICAL PHARMACOLOGY, 1990, 40 (06) : 1345 - 1350
[34] SYNTHESIS OF 1,2,3,4-TETRAHYDROACRIDINE AND 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES AS POTENTIAL ACETYLCHOLINESTERASE INHIBITORS
GATTA, F
DELGIUDICE, MR
POMPONI, M
MARTA, M
HETEROCYCLES, 1992, 34 (05) : 991 - 1004
[35] Synthesis of acetylcholinesterase inhibitors on the basis of 9-isothiocyanato-1,2,3,4-tetrahydroacridine:: 2-[1,2,3,4-tetrahydroacridin-9-yl)imino]-3-substituted 1,3-thiazolidin-4-ones
Kristian, P
Hamul'aková, S
Bernát, J
Imrich, J
Voss, G
Busová, T
HETEROCYCLES, 1998, 49 : 197 - 204
[36] 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (THA) BLOCKS AGONIST-INDUCED POTASSIUM CONDUCTANCE IN RAT HIPPOCAMPAL-NEURONS
HALLIWELL, JV
GROVE, EA
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 163 (2-3) : 369 - 372
[37] INHIBITION OF HISTAMINE-N-METHYLTRANSFERASE (HNMT) BY FRAGMENTS OF 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (TACRINE) AND BY BETA-CARBOLINES
CUMMING, P
VINCENT, SR
BIOCHEMICAL PHARMACOLOGY, 1992, 44 (05) : 989 - 992
[38] SOME ACTIONS OF 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE (THA) ON CHOLINERGIC TRANSMISSION AND MEMBRANE CURRENTS IN RAT SYMPATHETIC-GANGLIA
MARSH, SJ
HUBBARD, A
BROWN, DA
EUROPEAN JOURNAL OF NEUROSCIENCE, 1990, 2 (12) : 1127 - 1134
[39] C-11 YIELD IN REACTIONS BE-9(HE-3,N)C-11 AND BE-9(ALPHA,2N)C-11
KRASNOV, NN
DMITRIEV, PP
DMITRIEV.ZP
KONSTANT.IO
MOLIN, GA
SOVIET ATOMIC ENERGY-USSR, 1970, 28 (03): : 335 - &
[40] 9-[3-(2-NITRO-1-IMIDAZOLYL)PROPYLAMINO]-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE - A NOVEL DNA-AFFINIC HYPOXIC CELL CYTOTOXIN AND RADIOSENSITIZER - COMPARISON WITH NLA-1
PAPADOPOULOU, MV
ROSENZWEIG, HS
DODDI, M
BLOOMER, WD
ONCOLOGY RESEARCH, 1994, 6 (09) : 439 - 448

← 1 2 3 4 5 →