SYNTHESIS OF 9-[C-11]METHYLAMINO-1,2,3,4-TETRAHYDROACRIDINE, A POTENT ACETYLCHOLINE ESTERASE INHIBITOR

被引：0

作者：

BONNOT, S ^{[1
]}

PRENANT, C ^{[1
]}

CROUZEL, C ^{[1
]}

机构：

[1] CEA,DRIPP,SERV HOSP FREDERIC JOLIOT,F-91406 ORSAY,FRANCE

来源：

APPLIED RADIATION AND ISOTOPES | 1991年 / 42卷 / 07期

关键词：

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A method is described by which 3.7 GBq (100 mCi) of a derivative of tetrahydroaminoacridine (THA): N-[C-11]methyl THA may be obtained from about 55.5 GBq (1.5 Ci) of [C-11]CO2. THA is methylated with [C-11]methyl iodide after deprotonation by sodium hydride in dimethyl sulphoxide at 100-degrees-C. The specific activity averages 35 GBq/mu-mol (950 mCi/mu-mol) at the end of synthesis (total time of synthesis: 45 min from EOB).

引用

页码：690 / 691

页数：2

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