STUDIES ON THE EFFECT OF ASCORBIC-ACID AND SELENIUM ON THE GENOTOXICITY OF NITROFURANS - NITROFURAZONE AND FURAZOLIDONE

被引：30
|
作者：
GAJEWSKA, J [1 ]
SZCZYPKA, M [1 ]
TUDEK, B [1 ]
SZYMCZYK, T [1 ]
机构：
[1] MED ACAD WARSAW,INST BIOPHARM,DEPT BIOCHEM,WARSAW,POLAND
来源：
MUTATION RESEARCH | 1990年 / 232卷 / 02期
关键词：
Ames test; Antioxidants; Ascorbic acid; Furazolidone; Genotoxic activity; Nitrofurazone; Sodium selenite; SOS-chromotest;
D O I：
10.1016/0027-5107(90)90124-M
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The genotoxic properties of nitrofurazone and furazolidone were studied using the Ames test and SOS-chromotest. Both compounds were found to act as strong mutagens on the TA97 and TA102 strains of S. typhimurium and to induce the SOS-repair system in the PQ37 strain of E. coli. A good concordance was found between the mutagenic activity and the ability to induce the SOS system. Ascorbic acid and sodium selenite only very slightly lowered the genotoxic effect of the 2 nitrofurans studied both in the Ames test and in the SOS-chromotest. © 1990.
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页码：191 / 197
页数：7
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