A convenient one-pot synthesis of the title compound(I) has been achieved by reacting 8-acetyl-7-hydroxy-4-methylcoumarin in acetone solution with phenylacetyl chloride in the presence of potassium carbonate with an yield of 42%. A preliminary pharmacological testing of the compound on perfused frog heart shows a Digitalis glycosides-like action.
机构:
Department of Chemistry, Dartmouth College, Hanover,NH,03755, United StatesDepartment of Chemistry, Dartmouth College, Hanover,NH,03755, United States
Simon, Wendy M.
Trujillo, Hernando A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, Albright College, Reading,PA,19612, United StatesDepartment of Chemistry, Dartmouth College, Hanover,NH,03755, United States
Trujillo, Hernando A.
Pelkey, Erin T.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, Dartmouth College, Hanover,NH,03755, United StatesDepartment of Chemistry, Dartmouth College, Hanover,NH,03755, United States
Pelkey, Erin T.
Gribble, Gordon W.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, Dartmouth College, Hanover,NH,03755, United StatesDepartment of Chemistry, Dartmouth College, Hanover,NH,03755, United States
Gribble, Gordon W.
Jasinski, Jerry P.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, Keene State College, Keene,NH,03435-2001, United StatesDepartment of Chemistry, Dartmouth College, Hanover,NH,03755, United States