ALPHA-TOCOPHEROL PROTECTS AGAINST RADICAL-INDUCED INJURY IS CULTURED NEURONS

被引：14

作者：

AMANO, S ^{[1
]}

OHASHI, M ^{[1
]}

KIRIHARA, M ^{[1
]}

YANG, XH ^{[1
]}

HAZAMA, F ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI, DEPT NEUROSURG, OTSU, SHIGA 520210, JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

NEURON; CULTURED SYSTEM; ALPHA-TOCOPHEROL; RADICAL INJURY; CUMENE HYDROPEROXIDE; PROTECTION;

D O I：

10.1016/0304-3940(94)90237-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of alpha-tocopherol on neurons in protecting against radical-induced injuries caused by cumene hydroperoxide was assessed using a culture system. Structural and biochemical deteriorations in both clonal neuroblastoma cells and primary cultured neurons were induced by cumene hydroperoxide. These deteriorative changes were prevented by pretreatment of alpha-tocopherol. Since simultaneous supplementation of alpha-tocopherol and cumene hydroperoxide had limited protective effects, prophylactic administration of alpha-tocopherol for risk patients with brain diseases concerned with damages induced by free radical is recommended to hamper the progression of neuronal impairment after attacks.

引用

页码：55 / 58

页数：4

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