ALPHA-TOCOPHEROL PROTECTS AGAINST RADICAL-INDUCED INJURY IS CULTURED NEURONS

被引：14
|
作者：
AMANO, S [1 ]
OHASHI, M [1 ]
KIRIHARA, M [1 ]
YANG, XH [1 ]
HAZAMA, F [1 ]
机构：
[1] SHIGA UNIV MED SCI, DEPT NEUROSURG, OTSU, SHIGA 520210, JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期
关键词：
NEURON; CULTURED SYSTEM; ALPHA-TOCOPHEROL; RADICAL INJURY; CUMENE HYDROPEROXIDE; PROTECTION;
D O I：
10.1016/0304-3940(94)90237-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of alpha-tocopherol on neurons in protecting against radical-induced injuries caused by cumene hydroperoxide was assessed using a culture system. Structural and biochemical deteriorations in both clonal neuroblastoma cells and primary cultured neurons were induced by cumene hydroperoxide. These deteriorative changes were prevented by pretreatment of alpha-tocopherol. Since simultaneous supplementation of alpha-tocopherol and cumene hydroperoxide had limited protective effects, prophylactic administration of alpha-tocopherol for risk patients with brain diseases concerned with damages induced by free radical is recommended to hamper the progression of neuronal impairment after attacks.
引用
收藏
页码：55 / 58
页数：4
相关论文
共 50 条
  • [31] Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress
    Sarawoot Palipoch
    Chuchard Punsawad
    Phanit Koomhin
    Prasit Suwannalert
    BMC Complementary and Alternative Medicine, 14
  • [32] FORMATION OF ALPHA-TOCOPHEROL RADICAL AND RECYCLING OF ALPHA-TOCOPHEROL BY ASCORBATE DURING PEROXIDATION OF PHOSPHATIDYLCHOLINE LIPOSOMES - AN ELECTRON-PARAMAGNETIC RESONANCE STUDY
    SCARPA, M
    RIGO, A
    MAIORINO, M
    URSINI, F
    GREGOLIN, C
    BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 801 (02) : 215 - 219
  • [33] Hepatoprotective effect of curcumin and alpha-tocopherol against cisplatin-induced oxidative stress
    Palipoch, Sarawoot
    Punsawad, Chuchard
    Koomhin, Phanit
    Suwannalert, Prasit
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 14
  • [34] PROTECTION AGAINST ADRIAMYCIN-INDUCED SKIN NECROSIS IN THE RAT BY DIMETHYLSULFOXIDE AND ALPHA-TOCOPHEROL
    SVINGEN, BA
    POWIS, G
    APPEL, PL
    SCOTT, M
    CANCER RESEARCH, 1981, 41 (09) : 3395 - 3399
  • [35] Lithium protects cultured neurons against β-amyloid-induced neurodegeneration
    Alvarez, G
    Muñoz-Montaño, JR
    Satrústegui, J
    Avila, J
    Bogónez, E
    Díaz-Nido, J
    FEBS LETTERS, 1999, 453 (03) : 260 - 264
  • [36] alpha-tocopherol transfer protein stimulates the secretion of alpha-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway
    Arita, M
    Nomura, K
    Arai, H
    Inoue, K
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (23) : 12437 - 12441
  • [37] α-Tocopherol Succinate Protects Mice against Radiation-Induced Gastrointestinal Injury
    Singh, Pankaj K.
    Wise, Stephen Y.
    Ducey, Elizabeth J.
    Fatanmi, Oluseyi O.
    Elliott, Thomas B.
    Singh, Vijay K.
    RADIATION RESEARCH, 2012, 177 (02) : 133 - 145
  • [38] Nitric oxide-induced oxidation of alpha-tocopherol
    dIschia, M
    Novellino, L
    BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (10) : 1747 - 1753
  • [39] POTENTIAL EFFECTS OF ALPHA-TOCOPHEROL ON INDUCED PRIMATE ATHEROSCLEROSIS
    BUSH, M
    MILLER, M
    WEAVER, S
    VERLANGIERI, AJ
    FASEB JOURNAL, 1988, 2 (06): : A1597 - A1597
  • [40] Protective Effect of Alpha-Tocopherol in Deltamethrin Induced Immunotoxicity
    Kumar, Anoop
    Sharma, Ruchika
    Rana, Divya
    Sharma, Neelima
    ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2019, 19 (02) : 171 - 184
12345