ALPHA-TOCOPHEROL PROTECTS AGAINST RADICAL-INDUCED INJURY IS CULTURED NEURONS

被引：14
|
作者：
AMANO, S [1 ]
OHASHI, M [1 ]
KIRIHARA, M [1 ]
YANG, XH [1 ]
HAZAMA, F [1 ]
机构：
[1] SHIGA UNIV MED SCI, DEPT NEUROSURG, OTSU, SHIGA 520210, JAPAN
来源：
NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期
关键词：
NEURON; CULTURED SYSTEM; ALPHA-TOCOPHEROL; RADICAL INJURY; CUMENE HYDROPEROXIDE; PROTECTION;
D O I：
10.1016/0304-3940(94)90237-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of alpha-tocopherol on neurons in protecting against radical-induced injuries caused by cumene hydroperoxide was assessed using a culture system. Structural and biochemical deteriorations in both clonal neuroblastoma cells and primary cultured neurons were induced by cumene hydroperoxide. These deteriorative changes were prevented by pretreatment of alpha-tocopherol. Since simultaneous supplementation of alpha-tocopherol and cumene hydroperoxide had limited protective effects, prophylactic administration of alpha-tocopherol for risk patients with brain diseases concerned with damages induced by free radical is recommended to hamper the progression of neuronal impairment after attacks.
引用
收藏
页码：55 / 58
页数：4
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