RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引：51
|
作者：
CHUNG, HM
LEE, MGS
VANDERPLOEG, LHT
机构：
[1] COLUMBIA UNIV, DEPT GENET & DEV, NEW YORK, NY 10032 USA
[2] COLUMBIA UNIV, SCH PUBL HLTH, DIV TROP MED, NEW YORK, NY 10032 USA
来源：
PARASITOLOGY TODAY | 1992年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0169-4758(92)90194-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Protein-coding genes are transcribed by RNA polymerase (pol) II in all eukaryotes analyzed to date, with the exception of the protozoan Trypanosoma brucei, where pol I can mediate expression of chloramphenicol acetyl transferase (CAT) and neomycin phosphotransferase (neo) reporter genes. The addition of the capped 39-nucleotide (nt) mini-exon to the pre-messenger RNA (mRNA) by trans-splicing in T. brucei has presumably led to the uncoupling of the requirement for production of mRNA by pol II. Here Hui-min Chung Mary G-S. Lee and Lex Van der Ploeg review the evidence that supports the notion that pol I also transcribes a subset of naturally occurring protein-coding genes in T. brucei.
引用
收藏
页码：414 / 418
页数：5
相关论文
共 50 条
  • [41] EXPRESSION OF A RETROPOSON-LIKE SEQUENCE UPSTREAM OF THE PUTATIVE TRYPANOSOMA-BRUCEI VARIANT SURFACE GLYCOPROTEIN GENE-EXPRESSION SITE PROMOTER
    LODES, MJ
    SMILEY, BL
    STADNYK, AW
    BENNETT, JL
    MYLER, PJ
    STUART, K
    MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (11) : 7036 - 7044
  • [42] Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A
    Kirkham, Justin K.
    Park, Sung Hee
    Nguyen, Tu N.
    Lee, Ju Huck
    Guenzl, Arthur
    MOLECULAR AND CELLULAR BIOLOGY, 2016, 36 (01) : 95 - 107
  • [43] Analysis of equine protein-coding gene structure and expression by RNA-sequencing
    Stephen J Coleman
    Zheng Zeng
    Jinze Liu
    James N MacLeod
    BMC Bioinformatics, 11
  • [44] Analysis of equine protein-coding gene structure and expression by RNA-sequencing
    Coleman, Stephen J.
    Zeng, Zheng
    Liu, Jinze
    MacLeod, James N.
    BMC BIOINFORMATICS, 2010, 11
  • [45] 2 FORMS OF RPO41-DEPENDENT RNA-POLYMERASE - REGULATION OF THE RNA-POLYMERASE BY GLUCOSE REPRESSION MAY CONTROL YEAST MITOCHONDRIAL GENE-EXPRESSION
    WILCOXEN, SE
    PETERSON, CR
    WINKLEY, CS
    KELLER, MJ
    JAEHNING, JA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1988, 263 (25) : 12346 - 12351
  • [46] EXTRANUCLEAR GENE-EXPRESSION IN YEAST - EVIDENCE FOR A PLASMID-ENCODED RNA-POLYMERASE OF UNIQUE STRUCTURE
    WILSON, DW
    MEACOCK, PA
    NUCLEIC ACIDS RESEARCH, 1988, 16 (16) : 8097 - 8112
  • [47] VECTOR SYSTEM FOR GENE-EXPRESSION BASED ON THE USE OF BACTERIOPHAGE-T7 RNA-POLYMERASE
    ILIICHEV, AA
    MELAMED, NV
    ZAKABUNIN, AI
    PETRENKO, VA
    ZAGREBELNYI, SN
    DOKLADY AKADEMII NAUK SSSR, 1988, 303 (02): : 496 - &
  • [48] PHAGE RNA-POLYMERASE VECTORS THAT ALLOW EFFICIENT GENE-EXPRESSION IN BOTH PROKARYOTIC AND EUKARYOTIC CELLS
    HE, BA
    MCALLISTER, WT
    DURBIN, RK
    GENE, 1995, 164 (01) : 75 - 79
  • [49] TblncRNA-23, a long non-coding RNA transcribed by RNA polymerase I, regulates developmental changes in Trypanosoma brucei
    Beathrice Galili-Kostin
    K. Shanmugha Rajan
    Yuval Ida Ashkenazi
    Almog Freedman
    Tirza Doniger
    Smadar Cohen-Chalamish
    Hiba Waldman Ben-Asher
    Ron Unger
    Isabel Roditi
    Christian Tschudi
    Shulamit Michaeli
    Nature Communications, 16 (1)
  • [50] IDENTIFICATION OF A NEW EXPRESSION SITE-ASSOCIATED GENE IN THE COMPLETE 30.5 KB SEQUENCE FROM THE ANTAT 1.3A VARIANT SURFACE PROTEIN GENE-EXPRESSION SITE OF TRYPANOSOMA-BRUCEI
    LIPS, S
    REVELARD, P
    PAYS, E
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 62 (01) : 135 - 137
12345