RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引：51
|
作者：
CHUNG, HM
LEE, MGS
VANDERPLOEG, LHT
机构：
[1] COLUMBIA UNIV, DEPT GENET & DEV, NEW YORK, NY 10032 USA
[2] COLUMBIA UNIV, SCH PUBL HLTH, DIV TROP MED, NEW YORK, NY 10032 USA
来源：
PARASITOLOGY TODAY | 1992年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0169-4758(92)90194-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Protein-coding genes are transcribed by RNA polymerase (pol) II in all eukaryotes analyzed to date, with the exception of the protozoan Trypanosoma brucei, where pol I can mediate expression of chloramphenicol acetyl transferase (CAT) and neomycin phosphotransferase (neo) reporter genes. The addition of the capped 39-nucleotide (nt) mini-exon to the pre-messenger RNA (mRNA) by trans-splicing in T. brucei has presumably led to the uncoupling of the requirement for production of mRNA by pol II. Here Hui-min Chung Mary G-S. Lee and Lex Van der Ploeg review the evidence that supports the notion that pol I also transcribes a subset of naturally occurring protein-coding genes in T. brucei.
引用
收藏
页码：414 / 418
页数：5
相关论文
共 50 条
  • [21] TRYPANOSOMA-BRUCEI - POSTTRANSCRIPTIONAL CONTROL OF THE VARIABLE SURFACE GLYCOPROTEIN GENE-EXPRESSION SITE
    PAYS, E
    COQUELET, H
    PAYS, A
    TEBABI, P
    STEINERT, M
    MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) : 4018 - 4021
  • [22] Transcription of protein-coding genes in trypanosomes by RNA polymerase I
    Lee, MGS
    VanderPloeg, LHT
    ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 : 463 - 489
  • [23] CLONING AND TRANSCRIPTIONAL ANALYSIS OF A VARIANT SURFACE GLYCOPROTEIN GENE-EXPRESSION SITE IN TRYPANOSOMA-BRUCEI
    GIBBS, CP
    CROSS, GAM
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1988, 28 (03) : 197 - 206
  • [24] PROCYCLIN GENE-EXPRESSION AND LOSS OF THE VARIANT SURFACE GLYCOPROTEIN DURING DIFFERENTIATION OF TRYPANOSOMA-BRUCEI
    RODITI, I
    SCHWARZ, H
    PEARSON, TW
    BEECROFT, RP
    LIU, MK
    RICHARDSON, JP
    BUHRING, HJ
    PLEISS, J
    BULOW, R
    WILLIAMS, RO
    OVERATH, P
    JOURNAL OF CELL BIOLOGY, 1989, 108 (02): : 737 - 746
  • [25] MOLECULAR CHARACTERIZATION OF THE TRYPANOSOMA-BRUCEI RNA POLYMERASE-I AND POLYMERASE-III LARGEST SUBUNIT GENES
    SMITH, JL
    LEVIN, JR
    AGABIAN, N
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (30) : 18091 - 18099
  • [26] TRYPANOSOMA-BRUCEI - UNUSUAL EXPRESSION-SITE-ASSOCIATED GENE HOMOLOGIES IN A METACYCLIC VSG GENE-EXPRESSION SITE
    GRAHAM, SV
    MATTHEWS, KR
    BARRY, JD
    EXPERIMENTAL PARASITOLOGY, 1993, 76 (01) : 96 - 99
  • [27] The 5′ end structure of transcripts derived from the rRNA gene and the RNA polymerase I transcribed protein coding genes in Trypanosoma brucei
    Bruderer, T
    Tu, LC
    Lee, GS
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2003, 129 (01) : 69 - 77
  • [28] EXPRESSION OF A EUKARYOTIC PROTEIN-CODING GENE BY POLYMERASE-III
    ADENIYIJONES, S
    ROMERO, P
    ZASLOFF, M
    AMERICAN JOURNAL OF HUMAN GENETICS, 1983, 35 (06) : A168 - A168
  • [29] HIGH HOMOLOGY BETWEEN VARIANT SURFACE GLYCOPROTEIN GENE-EXPRESSION SITES OF TRYPANOSOMA-BRUCEI AND TRYPANOSOMA-GAMBIENSE
    THI, CDD
    AERTS, D
    STEINERT, M
    PAYS, E
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1991, 48 (02) : 199 - 210
  • [30] A TRANSFERRIN-BINDING PROTEIN OF TRYPANOSOMA-BRUCEI IS ENCODED BY ONE OF THE GENES IN THE VARIANT SURFACE GLYCOPROTEIN GENE-EXPRESSION SITE
    SCHELL, D
    EVERS, R
    PREIS, D
    ZIEGELBAUER, K
    KIEFER, H
    LOTTSPEICH, F
    CORNELISSEN, AWCA
    OVERATH, P
    EMBO JOURNAL, 1991, 10 (05): : 1061 - 1066
12345