RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引：51
|
作者：
CHUNG, HM
LEE, MGS
VANDERPLOEG, LHT
机构：
[1] COLUMBIA UNIV, DEPT GENET & DEV, NEW YORK, NY 10032 USA
[2] COLUMBIA UNIV, SCH PUBL HLTH, DIV TROP MED, NEW YORK, NY 10032 USA
来源：
PARASITOLOGY TODAY | 1992年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0169-4758(92)90194-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Protein-coding genes are transcribed by RNA polymerase (pol) II in all eukaryotes analyzed to date, with the exception of the protozoan Trypanosoma brucei, where pol I can mediate expression of chloramphenicol acetyl transferase (CAT) and neomycin phosphotransferase (neo) reporter genes. The addition of the capped 39-nucleotide (nt) mini-exon to the pre-messenger RNA (mRNA) by trans-splicing in T. brucei has presumably led to the uncoupling of the requirement for production of mRNA by pol II. Here Hui-min Chung Mary G-S. Lee and Lex Van der Ploeg review the evidence that supports the notion that pol I also transcribes a subset of naturally occurring protein-coding genes in T. brucei.
引用
收藏
页码：414 / 418
页数：5
相关论文
共 50 条
  • [1] RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI (PARASITOLOGY TODAY, VOL 12, PG 414, 1992)
    CHUNG, HM
    LEE, MGS
    VANDERPLOEG, LHT
    PARASITOLOGY TODAY, 1993, 9 (01): : 17 - 17
  • [2] RNA POLYMERASE-I CAN MEDIATE EXPRESSION OF CAT AND NEO PROTEIN-CODING GENES IN TRYPANOSOMA-BRUCEI
    RUDENKO, G
    CHUNG, HMM
    PHAM, VP
    VANDERPLOEG, LHT
    EMBO JOURNAL, 1991, 10 (11): : 3387 - 3397
  • [3] Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres
    Glover, L
    Horn, D
    EMBO REPORTS, 2006, 7 (01) : 93 - 99
  • [4] UNUSUAL RNA-POLYMERASE CONTENT OF TRYPANOSOMA-BRUCEI NUCLEI
    EARNSHAW, DL
    BEEBEE, TJC
    GUTTERIDGE, WE
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 131 (02) : 844 - 848
  • [5] TUBULIN GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI
    IMBODEN, M
    BLUM, B
    BRAUN, R
    SEEBECK, T
    EXPERIENTIA, 1986, 42 (06): : 689 - 689
  • [6] VARIABLE RNA-POLYMERASE POPULATIONS IN THE LIFE-CYCLE OF TRYPANOSOMA-BRUCEI
    TITTAWELLA, I
    FEBS LETTERS, 1988, 227 (02): : 122 - 126
  • [7] RNA-POLYMERASE I-MEDIATED EXPRESSION OF INFLUENZA VIRAL-RNA MOLECULES
    NEUMANN, G
    ZOBEL, A
    HOBOM, G
    VIROLOGY, 1994, 202 (01) : 477 - 479
  • [8] DEVELOPMENTAL REGULATION OF NUCLEAR GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI
    CLAYTON, C
    PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, 1992, 43 : 37 - 66
  • [9] MITOCHONDRIAL GENE-EXPRESSION DURING DEVELOPMENT IN TRYPANOSOMA-BRUCEI
    STUART, K
    FEAGIN, JE
    JASMER, DP
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 123 - 123
  • [10] EFFICIENT PRODUCTION OF FUNCTIONAL MESSENGER-RNA MEDIATED BY RNA POLYMERASE-I IN TRYPANOSOMA-BRUCEI
    ZOMERDIJK, JCBM
    KIEFT, R
    BORST, P
    NATURE, 1991, 353 (6346) : 772 - 775
12345