MILD OXIDATION OF 1,2,3,4-TETRAHYDRO-BETA-CARBOLINES

被引：0

作者：

MOKROSZ, MJ

PALUCHOWSKA, MH

MISZTAL, S

机构：

来源：

POLISH JOURNAL OF CHEMISTRY | 1995年 / 69卷 / 02期

关键词：

1,2,3,4-TETRAHYDRO-BETA-CARBOLINES; 3,4-DIHYDRO-BETA-CARBOLINES; SELECTIVE OXIDATION; OXIDATION WITH KMNO4 IN COLD THF; SUBSTITUENT EFFECT;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidation of 1-(aryl or heteroaryl)1,2,3,4-tetrahydro-beta-carbolines (1a-r) with KMnO4 in dry THF afforded in the most cases almost exclusively 3,4-dihydro products (2) with a yield of 28-94 %. Only in few cases (1c, 1i, 1m) the reaction was non-selective and a significant amount of the fully aromatized products (3) (30-40 % of the reaction mixture) was observed. The influence of both the substituent nature and the substitution modes on the observed yield and selectivity of the reaction was discussed.

引用

页码：264 / 268

页数：5

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