MILD OXIDATION OF 1,2,3,4-TETRAHYDRO-BETA-CARBOLINES

被引：0
|
作者：
MOKROSZ, MJ
PALUCHOWSKA, MH
MISZTAL, S
机构：
来源：
POLISH JOURNAL OF CHEMISTRY | 1995年 / 69卷 / 02期
关键词：
1,2,3,4-TETRAHYDRO-BETA-CARBOLINES; 3,4-DIHYDRO-BETA-CARBOLINES; SELECTIVE OXIDATION; OXIDATION WITH KMNO4 IN COLD THF; SUBSTITUENT EFFECT;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Oxidation of 1-(aryl or heteroaryl)1,2,3,4-tetrahydro-beta-carbolines (1a-r) with KMnO4 in dry THF afforded in the most cases almost exclusively 3,4-dihydro products (2) with a yield of 28-94 %. Only in few cases (1c, 1i, 1m) the reaction was non-selective and a significant amount of the fully aromatized products (3) (30-40 % of the reaction mixture) was observed. The influence of both the substituent nature and the substitution modes on the observed yield and selectivity of the reaction was discussed.
引用
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页码：264 / 268
页数：5
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