STUDIES TOWARDS THE SYNTHESIS OF OBTUSENYNE - SYNTHESIS OF THE HEXAHYDROOXONIN NUCLEUS

被引：27

作者：

CURTIS, NR ^{[1
]}

HOLMES, AB ^{[1
]}

LOONEY, MG ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 05期

关键词：

MEDIUM RING; UNSATURATED LACTONE; ENOLATE HYDROXYLATION; TEBBE METHYLENATION; HYDROSILATION;

D O I：

10.1016/S0040-4039(00)92339-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The advanced intermediate (the 2,3,4,7,8,9-hexahydrooxonin) 3 for the synthesis of the Laurencia oxonane natural product, obtusenyne 1 was prepared in 8 steps from the previously reported lactone 4. The key transformations were the stereoselective enolate hydroxylation of the lactone 4 and a hydroxyl-directed intramolecular hydrosilation of the enol ether 12.

引用

页码：671 / 674

页数：4

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