Studies towards the total synthesis of Sch 56036; isoquinolinone synthesis and the synthesis of phenanthrenes

被引：78
|
作者：
Walker, ER [1 ]
Leung, SY [1 ]
Barrett, AGM [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 38期
基金：
英国工程与自然科学研究理事会;
关键词：
Sch; 56036; albofungin; antifungal natural product; Pomeranz-Fritsch reaction; Palladium(0) coupling; ring closing metathesis; phenanthrene;
D O I：
10.1016/j.tetlet.2005.07.084
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The isoquinolinone hemisphere of Sch 56036 has been prepared using a modified Pomeranz-Fritsch reaction and the synthesis of the phenanthrene core has been modelled via a Suzuki coupling and subsequent ring closing metathesis. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6537 / 6540
页数：4
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