Ovarian stimulation with corifollitropin alfa

被引：0
|
作者：
Griesinger, G. [1 ,2 ,3 ]
Diedrich, K. [3 ]
Schultze-Mosgau, A. [1 ,2 ,3 ]
机构：
[1] Univ Klinikum Schleswig Holstein, UKL Univ Kinderwunschzentrum Lubeck, Zentrum Gynakol Endokrinol & Reprodukt Med, Lubeck, Germany
[2] Ambulanzzentrum UK S H GmbH, Med Versorgungszentrum, Kiel, Germany
[3] Univ Klinikum Schleswig Holstein, Klin Frauenheilkunde & Geburtshilfe, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany
来源：
GYNAKOLOGISCHE ENDOKRINOLOGIE | 2011年 / 9卷 / 04期
关键词：
Ovulation induction; Fertilization in vitro; Corifollitropin alfa; Gonadotropin-releasing hormone; Antagonist;
D O I：
10.1007/s10304-011-0432-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Corifollitropin alfa is a new hybrid protein of human follicle-stimulating hormone (FSH) and the C-terminal peptide of the beta-subunit of human chorionic gonadotropin. Due to a slower absorption and a longer terminal half-life, corifollitropin alfa can induce multifollicular development in women undergoing controlled ovarian stimulation using gonadotropin-releasing hormone (GnRH) antagonist-assisted in vitro fertilization (IVF). In two large randomized, double-blind, phase III trials, a single subcutaneous injection of corifollitropin alfa was as effective as 7 daily injections of recombinant FSH in inducing multifoil icular development when used as part of a GnRH antagonist protocol. Non-inferiority in ongoing pregnancy rates and numbers of oocytes available for IVF has been established. In another large phase III trial, non-immunogenicity of corifollitropin alfa has been demonstrated.
引用
收藏
页码：223 / 228
页数：6
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