PATH-ANALYSIS AND SIB-PAIR LINKAGE

被引：2

作者：

CAREY, G

WILLIAMSON, JA

机构：

[1] UNIV COLORADO, DEPT PSYCHOL, BOULDER, CO 80309 USA

[2] UNIV COLORADO, PROGRAM APPL MATH, BOULDER, CO 80309 USA

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 02期

关键词：

LINKAGE ANALYSIS; PATH ANALYSIS; SIB-PAIR METHOD;

D O I：

10.1002/gepi.1370100203

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed.

引用

页码：103 / 112

页数：10

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