PATH-ANALYSIS AND SIB-PAIR LINKAGE

被引：2
|
作者：
CAREY, G
WILLIAMSON, JA
机构：
[1] UNIV COLORADO, DEPT PSYCHOL, BOULDER, CO 80309 USA
[2] UNIV COLORADO, PROGRAM APPL MATH, BOULDER, CO 80309 USA
来源：
GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 02期
关键词：
LINKAGE ANALYSIS; PATH ANALYSIS; SIB-PAIR METHOD;
D O I：
10.1002/gepi.1370100203
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
When the distance between linked loci is expressed in terms of the correlation between the identity-by-descent (idb) values of the loci, then a path model may be used to order loci with data on sib-pairs and their parents. The relationship between the recombination fraction and the correlation coefficient is developed and a method for fitting a covariance matrix predicted by a specific ordering of loci to an observed covariance matrix is proposed.
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页码：103 / 112
页数：10
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