ENANTIOSELECTIVE REDUCTION OF DIETHYL 2-OXOALKYLPHOSPHONATES BY BAKERS-YEAST

被引：43
|
作者：
ZYMANCZYKDUDA, E
LEJCZAK, B
KAFARSKI, P
GRIMAUD, J
FISCHER, P
机构：
[1] WROCLAW TECH UNIV,INST ORGAN CHEM BIOCHEM & BIOTECHNOL,PL-50370 WROCLAW,POLAND
[2] ECOLE NATL SUPER CHIM MONTPELLIER,F-34053 MONTPELLIER,FRANCE
[3] UNIV STUTTGART,INST ORGAN CHEM & ISOTOPENFORSCH,W-7000 STUTTGART 80,GERMANY
来源：
TETRAHEDRON | 1995年 / 51卷 / 43期
关键词：
D O I：
10.1016/0040-4020(95)00742-Q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Baker's yeast catalyses the asymmetric reductive biotransformation of diethyl 2-oxoalkylphosphonates yielding diethyl 2-hydroxyalkylphosphonates in good yields and with high enantiomeric excess (>97%). As indicated by spectral analyses these hydroxyphosphonates exist in conformation which is ''frozen'' by intramolecular hydrogen bonding between phosphonate oxygen and hydroxyl hydrogen.
引用
收藏
页码：11809 / 11814
页数：6
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