N,N-DIMETHYL-2-[7-(METHYLAMINOSULFONYLMETHYL)-1-NAPHTHYL]ETHYLAMINE, THE NAPHTHALENIC BIOISOSTERE OF SUMATRIPTAN

被引：0
|
作者：
TINANT, B [1 ]
DECLERCQ, JP [1 ]
ABDELLAOUI, H [1 ]
DEPREUX, P [1 ]
LESIEUR, D [1 ]
机构：
[1] UNIV LILLE 2,INST CHIM PHARMACEUT,F-59006 LILLE,FRANCE
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1995年 / 51卷
关键词：
D O I：
10.1107/S0108270194011601
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The title molecule, C16H22N2O2S, is the naphthalenic bioisostere of sumatriptan, a well known agonist of the 5-hydroxytryptamine 5-HT1D receptor. The ethylamine side chain adopts an extended conformation (ac,ap,ap) and its plane is perpendicular to the naphthalene ring plane. This is very similar to that already observed in some analogous indole derivatives.
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页码：916 / 918
页数：3
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