STUDIES ON PYRIDAZINONE DERIVATIVES .15. OXIDATIVE REACTIONS AND ANTIBACTERIAL ANTIFUNGAL ACTIVITY OF SULFUR DERIVATIVES OF PYRIDAZINONE

被引：1
|
作者：
TAKAYA, M
机构：
[1] Hamari Chemical Co., Ltd., Higashiyodogawa-ku, Osaka 533, 1-4-29, Kunijima
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 09期
关键词：
ANTIMICROBIAL ACTIVITY; 2-PHENYL-3(2H)-PYRIDAZINONE; OXIDATIVE REACTION; SULFOXIDE; SULFONE; HYDROGEN PEROXIDE;
D O I：
10.1248/yakushi1947.113.9_676
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Oxidative reactions of o-nitrophenylthio substituted 2-phenyl-3(2H)-pyridazinones (3, 4, 13) with hydrogen peroxide were examined and o-nitrophenylsulfinyl compounds (5, 7, 14) and o-nitrophenylsulfonyl compound (6) were obtained. As the results of antibacterial antifungal screening tests in vitro, 3, 5 and 6 revealed strong antitrichophyton activities.
引用
收藏
页码：676 / 681
页数：6
相关论文
共 50 条
  • [41] IMIDAZOLE DERIVATIVES .15. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF BENZOLIN DERIVATIVES
    IRADYAN, MA
    AROYAN, RA
    AKOPYAN, VP
    KTSOYAN, LA
    AROYAN, AA
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1980, 14 (01): : 49 - 55
  • [42] STUDIES ON BENZOHETEROCYCLIC DERIVATIVES .15. SYNTHESIS OF BENZOFURAN DERIVATIVES .3.
    HIROSE, N
    KURIYAMA, S
    SOHDA, S
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1974, 94 (08): : 905 - 912
  • [43] STUDIES ON QUINOLIZINE DERIVATIVES .21. THE SYNTHESES OF CYCLAZINE DERIVATIVES .15.
    MATSUDA, Y
    TOMINAGA, Y
    AWAYA, H
    KURATA, K
    KATOU, K
    GOTOU, H
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1987, 107 (05): : 344 - 349
  • [44] THE SYNTHESIS AND SPECTRAL STUDIES OF PYRAZOLE DERIVATIVES PROVEN EFFECTIVE AS ANTIBACTERIAL & ANTIFUNGAL ACTIVITY
    Jadhav, Archanad
    Barhate, Pankaj U.
    Durrani, Ayesha N.
    HETEROCYCLIC LETTERS, 2020, 10 (03): : 439 - 445
  • [45] Synthesis and anti-inflammatory activity of novel pyridazine and pyridazinone derivatives as non-ulcerogenic agents
    Makarem M. Saeed
    Nadia A. Khalil
    Eman M. Ahmed
    Kholoud I. Eissa
    Archives of Pharmacal Research, 2012, 35 : 2077 - 2092
  • [46] TRICYCLIC 3-(2H)-PYRIDAZINONE DERIVATIVES - SYNTHESIS AND EVALUATION OF THEIR ANTISECRETORY AND ANTIULCER ACTIVITY
    CIGNARELLA, G
    BARLOCCO, D
    VILLA, S
    CURZU, MM
    PINNA, GA
    LAVEZZO, A
    BESTETTI, A
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (08) : 819 - 823
  • [47] Activity prediction of hepatitis C virus NS5B polymerase inhibitors of pyridazinone derivatives
    Chen, Jing
    Zhang, Liping
    Guo, Huixia
    Wang, Shixia
    Wang, Li
    Ma, Linlin
    Lu, Xiaoquan
    CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2014, 134 : 100 - 109
  • [48] ANTIBACTERIAL AND ANTIFUNGAL AGENTS .15. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF STRUCTURAL ANALOGS OF BIFONAZOLE AND KETOCONAZOLE
    STEFANCICH, G
    ARTICO, M
    ORTAR, G
    SILVESTRI, R
    SIMONETTI, G
    APUZZO, G
    ARTICO, M
    ARCHIV DER PHARMAZIE, 1992, 325 (11) : 687 - 694
  • [49] Design, Synthesis, and Herbicidal Activity of Biaryl-Pyridazinone/Phthalimide Derivatives as Novel Protoporphyrinogen Oxidase Inhibitors
    Pang, Chen
    Zhang, Meng
    Cai, Hui
    Song, Chaoyang
    Jin, Zhichao
    Ren, Shi-Chao
    Chi, Yonggui Robin
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2025, 73 (11) : 6458 - 6467
  • [50] Synthesis and antitumor activity of novel pyridazinone derivatives containing 1,3,4-thiadiazole moiety
    Qin, Junhu
    Zhu, Mei
    Zhu, Hongmei
    Zhang, Liqiong
    Fu, Yihong
    Liu, Jiamin
    Wang, Zhenchao
    OuYang, Guiping
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2020, 195 (07) : 592 - 599
12345