STUDIES ON PYRIDAZINONE DERIVATIVES .15. OXIDATIVE REACTIONS AND ANTIBACTERIAL ANTIFUNGAL ACTIVITY OF SULFUR DERIVATIVES OF PYRIDAZINONE

被引：1
|
作者：
TAKAYA, M
机构：
[1] Hamari Chemical Co., Ltd., Higashiyodogawa-ku, Osaka 533, 1-4-29, Kunijima
来源：
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 09期
关键词：
ANTIMICROBIAL ACTIVITY; 2-PHENYL-3(2H)-PYRIDAZINONE; OXIDATIVE REACTION; SULFOXIDE; SULFONE; HYDROGEN PEROXIDE;
D O I：
10.1248/yakushi1947.113.9_676
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Oxidative reactions of o-nitrophenylthio substituted 2-phenyl-3(2H)-pyridazinones (3, 4, 13) with hydrogen peroxide were examined and o-nitrophenylsulfinyl compounds (5, 7, 14) and o-nitrophenylsulfonyl compound (6) were obtained. As the results of antibacterial antifungal screening tests in vitro, 3, 5 and 6 revealed strong antitrichophyton activities.
引用
收藏
页码：676 / 681
页数：6
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