Structural and functional insights into putative TAG accumulating hydrolase protein (Rv1179c) of Mycobacterium tuberculosis H37Rv

被引：2
|
作者：
Sinha, Rajesh [1 ,4 ]
Singh, Pooja [2 ]
Natha, Onkar [1 ]
Mangangcha, Irengbam Rocky [1 ]
Kumar, Ajit [3 ]
Singh, Indrakant K. [1 ]
机构：
[1] Univ Delhi, Deshbandhu Coll, Dept Zool, Mol Biol Res Lab, Delhi, India
[2] Rutgers State Univ, Publ Hlth Res Inst, NJMS, Newark, NJ USA
[3] SRM Univ, Dept Chem, Sonepat, Haryana, India
[4] Cornell Univ, Dept Pharmacol, Weill Cornell Med Coll, 1300 York Ave, New York, NY 10065 USA
来源：
GENE REPORTS | 2018年 / 13卷
关键词：
TAG; Rv1179c; Mycobacterium tuberculosis; Hydrolase; I-Tasser;
D O I：
10.1016/j.genrep.2018.08.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Mycobacterium tuberculosis persistence in the host is one of the major challenges towards treating tuberculosis. A dedicated set of lipid metabolism genes enable it to resist anti-tuberculosis drugs. Host TAG accumulation is one such property displayed by Mycobacterium. We analyzed expression profile of mycobacterial genes under stress condition inducing TAG accumulation. TAG accumulation was accompanied by overexpression of Rv1179c. Structural analysis of Rv1179c suggests hydrolase like activity of Rv1179c. Hydrolases are involved in host lipid import and TAG accumulation.
引用
收藏
页码：66 / 71
页数：6
相关论文
共 50 条
  • [31] A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome
    Poonam Chitale
    Alexander D. Lemenze
    Emily C. Fogarty
    Avi Shah
    Courtney Grady
    Aubrey R. Odom-Mabey
    W. Evan Johnson
    Jason H. Yang
    A. Murat Eren
    Roland Brosch
    Pradeep Kumar
    David Alland
    Nature Communications, 13 (1)
  • [32] Crystal Structure of Sulfotransferase from Mycobacterium tuberculosis H37Rv
    Kakuta, Yoshimitsu
    Tanaka, Shotaro
    Moriizumi, Yuuji
    Kimura, Makoto
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2005, 61 : C201 - C201
  • [33] STUDIES ON MECHANISM OF ISONIAZID RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS H37RV
    SRIPRAKASH, KS
    RAMAKRISHNAN, T
    INDIAN JOURNAL OF BIOCHEMISTRY, 1968, 5 (04): : 185 - +
  • [34] NICOTINAMIDE-ADENINE NUCLEOTIDES OF MYCOBACTERIUM TUBERCULOSIS H37RV
    GOPINATHAN, KP
    SIRSI, M
    RAMAKRISHNAN, T
    BIOCHEMICAL JOURNAL, 1963, 87 (02) : 444 - &
  • [35] ISOLATION AND PURIFICATION OF SULFOLIPIDS OF MYCOBACTERIUM-TUBERCULOSIS, H37RV
    PRABHUDESAI, AV
    MALIK, U
    SUBRAHMANYAM, D
    KHULLER, GK
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 1981, 18 (01): : 71 - 73
  • [36] Learning from the genome sequence of Mycobacterium tuberculosis H37Rv
    Cole, ST
    FEBS LETTERS, 1999, 452 (1-2) : 7 - 10
  • [37] STUDIES OF THE CATALASE ACTIVITY OF MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV
    TYSAROWSKI, W
    KWIEK, S
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1959, 80 (02): : 257 - 258
  • [38] Cloning, expression, purification and crystallization of a transcriptional regulatory protein (Rv3291c) from Mycobacterium tuberculosis H37Rv
    Shrivastava, T
    Kumar, S
    Ramachandran, R
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2004, 60 : 1874 - 1876
  • [39] The multiple activities of polyphosphate kinase of Mycobacterium tuberculosis H37Rv
    Hwang, M. -R.
    Yoon, J. W.
    Park, S. -K.
    Kim, N. -I.
    Jung, H. -S.
    Kim, H. -Y.
    FEBS JOURNAL, 2008, 275 : 405 - 405
  • [40] Dehalogenation of haloalkanes by Mycobacterium tuberculosis H37Rv and other mycobacteria
    Jesenská, A
    Sedlácek, I
    Damborsky, J
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (01) : 219 - 222
12345