Structural and functional insights into putative TAG accumulating hydrolase protein (Rv1179c) of Mycobacterium tuberculosis H37Rv

被引：2

作者：

Sinha, Rajesh ^{[1
,4
]}

Singh, Pooja ^{[2
]}

Natha, Onkar ^{[1
]}

Mangangcha, Irengbam Rocky ^{[1
]}

Kumar, Ajit ^{[3
]}

Singh, Indrakant K. ^{[1
]}

机构：

[1] Univ Delhi, Deshbandhu Coll, Dept Zool, Mol Biol Res Lab, Delhi, India

[2] Rutgers State Univ, Publ Hlth Res Inst, NJMS, Newark, NJ USA

[3] SRM Univ, Dept Chem, Sonepat, Haryana, India

[4] Cornell Univ, Dept Pharmacol, Weill Cornell Med Coll, 1300 York Ave, New York, NY 10065 USA

来源：

GENE REPORTS | 2018年 / 13卷

关键词：

TAG; Rv1179c; Mycobacterium tuberculosis; Hydrolase; I-Tasser;

D O I：

10.1016/j.genrep.2018.08.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mycobacterium tuberculosis persistence in the host is one of the major challenges towards treating tuberculosis. A dedicated set of lipid metabolism genes enable it to resist anti-tuberculosis drugs. Host TAG accumulation is one such property displayed by Mycobacterium. We analyzed expression profile of mycobacterial genes under stress condition inducing TAG accumulation. TAG accumulation was accompanied by overexpression of Rv1179c. Structural analysis of Rv1179c suggests hydrolase like activity of Rv1179c. Hydrolases are involved in host lipid import and TAG accumulation.

引用

页码：66 / 71

页数：6

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