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Univ Edinbugh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh Bioquarter, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland Univ Edinbugh, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh Bioquarter, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland