Calcium handling and atrial fibrillation

被引：0

作者：

Heijman, Jordi ^{[1
]}

Voigt, Niels ^{[1
]}

Nattel, Stanley ^{[2
,3
]}

Dobrev, Dobromir ^{[1
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Div Expt Cardiol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany

[2] Montreal Heart Inst, Dept Med, Montreal, PQ, Canada

[3] Univ Montreal, Montreal, PQ, Canada

来源：

WIENER MEDIZINISCHE WOCHENSCHRIFT | 2012年 / 162卷 / 13-14期

关键词：

Atrial fibrillation; Atrial remodeling; Calcium handling; Ectopic activity;

D O I：

10.1007/s10354-012-0109-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca2+-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca2+ handling for AF pathophysiology.

引用

页码：287 / 291

页数：5

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