Calcium handling and atrial fibrillation

被引：0
|
作者：
Heijman, Jordi [1 ]
Voigt, Niels [1 ]
Nattel, Stanley [2 ,3 ]
Dobrev, Dobromir [1 ]
机构：
[1] Heidelberg Univ, Med Fac Mannheim, Div Expt Cardiol, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany
[2] Montreal Heart Inst, Dept Med, Montreal, PQ, Canada
[3] Univ Montreal, Montreal, PQ, Canada
来源：
WIENER MEDIZINISCHE WOCHENSCHRIFT | 2012年 / 162卷 / 13-14期
关键词：
Atrial fibrillation; Atrial remodeling; Calcium handling; Ectopic activity;
D O I：
10.1007/s10354-012-0109-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca2+-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca2+ handling for AF pathophysiology.
引用
收藏
页码：287 / 291
页数：5
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