ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

被引:0
|
作者
KALISH, V [1 ]
KALDOR, S [1 ]
SHETTY, B [1 ]
TATLOCK, J [1 ]
DAVIES, J [1 ]
HAMMOND, M [1 ]
DRESSMAN, B [1 ]
FRITZ, J [1 ]
APPELT, K [1 ]
REICH, S [1 ]
MUSICK, L [1 ]
WU, BW [1 ]
SU, K [1 ]
机构
[1] ELI LILLY & CO,INDIANAPOLIS,IN 46285
关键词
HIV PROTEASE INHIBITORS; STRUCTURE-BASED DRUG DESIGN; AG1343; AIDS;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
下载
收藏
页码:S201 / S214
页数:14
相关论文
共 50 条
  • [41] Structure-based design: Synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors
    Ghosh, AK
    Swanson, LM
    Cho, HN
    Leshchenko, S
    Hussain, KA
    Kay, S
    Walters, DE
    Koh, Y
    Mitsuya, H
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (10) : 3576 - 3585
  • [42] STRUCTURE-BASED DRUG DESIGN WITH HIV INTEGRASE.
    Greenwald, J.
    Vix, O.
    Farnet, C.
    Bushman, P.
    Choe, S.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 1996, 52 : C204 - C204
  • [43] Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors
    Namoto, Kenji
    Sirockin, Finton
    Sellner, Holger
    Wiesmann, Christian
    Villard, Frederic
    Moreau, Robert J.
    Valeur, Eric
    Paulding, Stephanie C.
    Schleeger, Simone
    Schipp, Kathrin
    Loup, Joachim
    Andrews, Lori
    Swale, Ryann
    Robinson, Michael
    Farady, Christopher J.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (05) : 906 - 909
  • [44] STRUCTURE-BASED DESIGN OF HIV-1 PROTEASE INHIBITORS EMPLOYING A SIMPLE METHOD FOR PREDICTING ACTIVITY
    HOLLOWAY, MK
    WAI, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 207 : 87 - COMP
  • [45] Structure-based design and solid phase synthesis of cysteine protease inhibitors for parasitic diseases.
    Gong, BQ
    Chen, XW
    Cheng, MS
    Li, RS
    Kenyon, GL
    Cohen, FE
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 39 - MEDI
  • [46] STRUCTURE OF A NONPEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE - DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
    RUTENBER, E
    FAUMAN, EB
    KEENAN, RJ
    FONG, S
    FURTH, PS
    DEMONTELLANO, PRO
    MENG, E
    KUNTZ, ID
    DECAMP, DL
    SALTO, R
    ROSE, JR
    CRAIK, CS
    STROUD, RM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (21) : 15343 - 15346
  • [47] THE DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS
    YOUNG, SD
    ANDERSON, PS
    DARKE, PL
    DAVIS, LJ
    DESOLMS, SJ
    DIXON, RAF
    EMINI, E
    GAFFIN, N
    GUARE, JP
    HUFF, JR
    ROBERTSON, G
    SANDERS, WM
    SIGAL, IS
    SCHLEIF, W
    VACCA, JP
    WIGGINS, JM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1990, 200 : 84 - MEDI
  • [48] Structure-based design of protease inhibitors as therapeutics: Some examples.
    Reich, SH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 219 : U595 - U595
  • [49] A Novel Strategy for the Structure-based Drug Design of Heat Shock Protein 90 Inhibitors
    Chen, Omix Yu-Chian
    Chen, Guan-Wen
    Chen, WinstonYu-Chen
    2008 IEEE INTERNATIONAL JOINT CONFERENCE ON NEURAL NETWORKS, VOLS 1-8, 2008, : 1199 - 1206
  • [50] Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates
    Williams, DH
    Mitchell, T
    CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (05) : 567 - 573