ITERATIVE PROTEIN STRUCTURE-BASED DRUG DESIGN AND SYNTHESIS OF HIV PROTEASE INHIBITORS

被引：0

作者：

KALISH, V ^{[1
]}

KALDOR, S ^{[1
]}

SHETTY, B ^{[1
]}

TATLOCK, J ^{[1
]}

DAVIES, J ^{[1
]}

HAMMOND, M ^{[1
]}

DRESSMAN, B ^{[1
]}

FRITZ, J ^{[1
]}

APPELT, K ^{[1
]}

REICH, S ^{[1
]}

MUSICK, L ^{[1
]}

WU, BW ^{[1
]}

SU, K ^{[1
]}

机构：

[1] ELI LILLY & CO,INDIANAPOLIS,IN 46285

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1995年 / 30卷

关键词：

HIV PROTEASE INHIBITORS; STRUCTURE-BASED DRUG DESIGN; AG1343; AIDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

下载

页码：S201 / S214

页数：14

共 50 条

[21] Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors
Scheidt, KA
Roush, WR
McKerrow, JH
Selzer, PM
Hansell, E
Rosenthal, PJ
BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (12) : 2477 - 2494
[22] Structure-based design of nonpeptidic HIV protease inhibitors: The sulfonamide-substituted cyclooctylpyranones
Skulnick, HI
Johnson, PD
Aristoff, PA
Morris, JK
Lovasz, KD
Howe, WJ
Watenpaugh, KD
Janakiraman, MN
Anderson, DJ
Reischer, RJ
Schwartz, TM
Banitt, LS
Tomich, PK
Lynn, JC
Horng, MM
Chong, KT
Hinshaw, RR
Dolak, LA
Seest, EP
Schwende, FJ
Rush, BD
Howard, GM
Toth, LN
Wilkinson, KR
Kakuk, TJ
Johnson, CW
Cole, SL
Zaya, RM
Zipp, GL
Possert, PL
Dalga, RJ
Zhong, WZ
Williams, MG
Romines, KR
JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (07) : 1149 - 1164
[23] Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds
Murphy, PV
O'Brien, JL
Gorey-Feret, LJ
Smith, AB
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (13) : 1763 - 1766
[24] Nonpeptidal P-2 ligands for HIV protease inhibitors: Structure-based design, synthesis, and biological evaluation
Ghosh, AK
Kincaid, JF
Walters, DE
Chen, Y
Chaudhuri, NC
Thompson, WJ
Culberson, C
Fitzgerald, PMD
Lee, HY
McKee, SP
Munson, PM
Duong, TT
Darke, PL
Zugay, JA
Schleif, WA
Axel, MG
Lin, J
Huff, JR
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (17) : 3278 - 3290
[25] PROTEIN STRUCTURE-BASED DRUG DESIGN
WHITTLE, PJ
BLUNDELL, TL
ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1994, 23 : 349 - 375
[26] Structure-Based Design, Synthesis, and Structure-Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones
Ali, Akbar
Reddy, G. S. Kiran Kumar
Nalam, Madhavi N. L.
Anjum, Saima Ghafoor
Cao, Hong
Schiffer, Celia A.
Rana, Tariq M.
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (21) : 7699 - 7708
[27] Structure-based design, synthesis, and crystallographic studies of novel HIV-1 protease inhibitors with enhanced backbone interactions
Osswald, Heather
Martyr, Cuthbert
Ghosh, Arun
Agniswamy, Johnson
Wang, Yuan-Fang
Amano, Masayuki
Weber, Irene
Mitsuya, Hiroaki
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
[28] Structure-based design and synthesis of substituted 2-butanols as nonpeptidic inhibitors of HIV protease: Secondary amide series
Reich, SH
Melnick, M
Pino, MJ
Fuhry, MAM
Trippe, AJ
Appelt, K
Davies, JF
Wu, BW
Musick, L
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (14) : 2781 - 2794
[29] Structure-based design of sulfonamide-substituted non-peptidic HIV protease inhibitors
Skulnick, HI
Johnson, PD
Howe, WJ
Tomich, PK
Chong, KT
Watenpaugh, KD
Janakiraman, MN
Dolak, LA
McGrath, JP
Lynn, JC
Horng, MM
Hinshaw, RR
Zipp, GL
Ruwart, MJ
Schwende, FJ
Zhong, WZ
Padbury, GE
Dalga, RJ
Shiou, LH
Possert, PL
Rush, BD
Wilkinson, KF
Howard, GM
Toth, LN
Williams, MG
Kakuk, TJ
Cole, SL
Zaya, RM
Lovasz, KD
Morris, JK
Romines, KR
Thaisrivongs, S
Aristoff, PA
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (26) : 4968 - 4971
[30] STRUCTURE-BASED DESIGN OF C2 SYMMETRICAL INHIBITORS OF HIV-1 PROTEASE
ERICKSON, J
NEIDHART, D
KEMPF, D
NORBECK, D
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1991, 4 (03): : 306 - 306

← 1 2 3 4 5 →