FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY CHROMOBACTERIUM-VIOLACEUM NO-968 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, AND ANTITUMOR-ACTIVITY

被引：0

作者：

UEDA, H

NAKAJIMA, H

HORI, Y

FUJITA, T

NISHIMURA, M

GOTO, T

OKUHARA, M

机构：

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.

引用

页码：301 / 310

页数：10

共 43 条

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OKAMOTO, M
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[32] UK-1, A NOVEL CYTOTOXIC METABOLITE FROM STREPTOMYCES SP 517-02 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
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[33] NF00659A(1), A(2), A(3), B-1 and B-2, novel antitumor antibiotics produced by Aspergillus sp. NF 00659 .1. Taxonomy, fermentation, isolation and biological activities
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[34] R1128 SUBSTANCES, NOVEL NONSTEROIDAL ESTROGEN-RECEPTOR ANTAGONISTS PRODUCED BY A STREPTOMYCES .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
HORI, Y
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GOTO, T
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JOURNAL OF ANTIBIOTICS, 1993, 46 (07): : 1055 - 1062
[35] Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus .1. Taxonomy, fermentation, isolation and biological properties
Cui, CB
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Onose, R
Osada, H
JOURNAL OF ANTIBIOTICS, 1996, 49 (06): : 527 - 533
[36] AT2433-A1, AT2433-A2, AT2433-B1, AND AT2433-B2 NOVEL ANTITUMOR ANTIBIOTIC COMPOUNDS PRODUCED BY ACTINOMADURA-MELLIAURA - TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
MATSON, JA
CLARIDGE, C
BUSH, JA
TITUS, J
BRADNER, WT
DOYLE, TW
HORAN, AC
PATEL, M
JOURNAL OF ANTIBIOTICS, 1989, 42 (11): : 1547 - 1555
[37] Schizostatin, a novel squalene synthase inhibitor produced by the mushroom, Schizophyllum commune .1. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities
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JOURNAL OF ANTIBIOTICS, 1996, 49 (07): : 617 - 623
[38] FR901451, A NOVEL INHIBITOR OF HUMAN-LEUKOCYTE ELASTASE FROM FLEXIBACTER SP .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
FUJITA, T
HATANAKA, H
HAYASHI, K
SHIGEMATSU, N
TAKASE, S
OKAMOTO, M
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SHIMATANI, K
SATOH, A
JOURNAL OF ANTIBIOTICS, 1994, 47 (12): : 1359 - 1364
[39] JANTHINOCIN-A, JANTHINOCIN-B AND JANTHINOCIN-C, NOVEL PEPTIDE LACTONE ANTIBIOTICS PRODUCED BY JANTHINOBACTERIUM-LIVIDUM .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL CHARACTERIZATION
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DEAN, L
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JOURNAL OF ANTIBIOTICS, 1990, 43 (08): : 913 - 919
[40] GYPSETIN, A NEW INHIBITOR OF ACYL-COA - CHOLESTEROL ACYLTRANSFERASE PRODUCED BY NANNIZZIA-GYPSEA VAR INCURVATA IFO-9228 .1. FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY
SHINOHARA, C
HASUMI, K
TAKEI, Y
ENDO, A
JOURNAL OF ANTIBIOTICS, 1994, 47 (02): : 163 - 167

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