FR901228, A NOVEL ANTITUMOR BICYCLIC DEPSIPEPTIDE PRODUCED BY CHROMOBACTERIUM-VIOLACEUM NO-968 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, AND ANTITUMOR-ACTIVITY

被引：0

作者：

UEDA, H

NAKAJIMA, H

HORI, Y

FUJITA, T

NISHIMURA, M

GOTO, T

OKUHARA, M

机构：

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.

引用

页码：301 / 310

页数：10

共 43 条

[21] QUINOLIDOMICINS A(1), A(2) AND B(1), NOVEL 60-MEMBERED MACROLIDE ANTIBIOTICS .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITY
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[23] VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET-AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA-NIGRA .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
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[24] A family of novel macrocyclic lactones, the saccharocarcins produced by Saccharothrix aerocolonigenes subsp antibiotica .1. Taxonomy, fermentation, isolation and biological properties
Horan, AC
Shearer, MC
Hegde, V
Beyazova, ML
Brodsky, BC
King, A
Berrie, R
Cardaci, K
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JOURNAL OF ANTIBIOTICS, 1997, 50 (02): : 119 - 125
[25] PHOSPHONOTHRIXIN, A NOVEL HERBICIDAL ANTIBIOTIC PRODUCED BY SACCHAROTHRIX SP ST-888 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
TAKAHASHI, E
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NAKAMURA, K
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JOURNAL OF ANTIBIOTICS, 1995, 48 (10): : 1124 - 1129
[26] GE3, a novel hexadepsipeptide antitumor antibiotic, produced by Streptomyces sp. .1. Taxonomy, production, isolation, physico-chemical properties, and biological activities
Sakai, Y
Yoshida, T
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Tanaka, F
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Akinaga, S
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JOURNAL OF ANTIBIOTICS, 1997, 50 (08): : 659 - 664
[27] NOVEL ANTIFUNGAL ANTIBIOTICS MANIWAMYCIN-A AND MANIWAMYCIN-B .1. TAXONOMY OF THE PRODUCING ORGANISM, FERMENTATION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL PROPERTIES
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[28] CHRYMUTASINS - NOVEL-AGLYCONE ANTITUMOR ANTIBIOTICS FROM A MUTANT OF STREPTOMYCES-CHARTREUSIS .1. TAXONOMY, MUTATION, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES
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[29] MYROCIN-C, A NEW DITERPENE ANTITUMOR ANTIBIOTIC FROM MYROTHECIUM-VERRUCARIA .1. TAXONOMY OF THE PRODUCING STRAIN, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
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[30] NOVEL ANTIFUNGAL ANTIBIOTICS OCTACOSAMICIN-A AND OCTACOSAMICIN-B .1. TAXONOMY, FERMENTATION AND ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES
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JOURNAL OF ANTIBIOTICS, 1988, 41 (11): : 1525 - 1532

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