SYSTEMIC LUPUS-ERYTHEMATOSUS INDUCED BY ISONIAZID

被引：26
|
作者：
SALAZARPARAMO, M
RUBIN, RL
GARCIADELATORRE, I
机构：
[1] HOSP GEN OCCIDENTE SEGURO SOCIAL, DEPT IMMUNOL & RHEUMATOL, AVE ZOQUIPAN 1050, JALISCO 45170, MEXICO
[2] SCRIPPS RES INST, CTR AUTOIMMUNE DIS, LA JOLLA, CA 92037 USA
来源：
ANNALS OF THE RHEUMATIC DISEASES | 1992年 / 51卷 / 09期
关键词：
D O I：
10.1136/ard.51.9.1085
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleohistone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.
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页码：1085 / 1087
页数：3
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