ANTICANCER ACTIVITIES OF ORALLY-ADMINISTERED MENOGARIL AGAINST HUMAN STOMACH AND BREAST CANCERS IMPLANTED IN NUDE-MICE

被引：0

作者：

INABA, M ^{[1
]}

SATO, S ^{[1
]}

YAMORI, T ^{[1
]}

TASHIRO, T ^{[1
]}

OHNISHI, Y ^{[1
]}

MARUO, K ^{[1
]}

UEYAMA, Y ^{[1
]}

TSURUO, T ^{[1
]}

机构：

[1] INST EXPTL ANIM,MIYAMAE KU,KAWASAKI,KANAGAWA 211,JAPAN

来源：

ANTICANCER RESEARCH | 1992年 / 12卷 / 6B期

关键词：

MENOGARIL; ANTITUMOR EFFECTS; STOMACH CANCERS; BREAST CANCERS; NUDE MOUSE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic effects of orally administered menogaril, a semisynthetic analog of the anthracycline antibiotic nogalamycin, were studied on a panel of human stomach and breast cancer xenografts. The maximum tolerated dose (200 mg/kg) of menogaril was administered 3 times every 4 days and its growth-inhibitory effects on subcutaneously implanted tumors in nude mice were evaluated. Menogaril significantly retarded the growth of 3 out of 7 stomach cancers, SC-2, SC-9 and 4-1ST, and 3 out of 4 breast cancers, H-31, MC-2 and MX-1, with overall response rates of 43 and 75% for stomach and breast cancers, respectively. Some of these relatively responsive cancers were also treated by daily oral administration for 5 consecutive days, but the anticancer effects of the intermittent administration seemed to be better. These results suggest that menogaril may be effective against stomach and breast cancers when orally administered.

引用

页码：1953 / 1956

页数：4

共 27 条

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[23] INVIVO STUDIES BY MAGNETIC-RESONANCE-IMAGING AND SPECTROSCOPY OF THE RESPONSE TO TAMOXIFEN OF MCF7 HUMAN BREAST-CANCER IMPLANTED IN NUDE-MICE
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[24] EVALUATION OF ANTITUMOR-ACTIVITY OF NAVELBINE (VINORELBINE DITARTRATE) AGAINST HUMAN BREAST-CARCINOMA XENOGRAFTS BASED ON ITS PHARMACOKINETICS IN NUDE-MICE
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[25] STABILITY OF IN-111 LABELED MONOCLONAL-ANTIBODY AGAINST HUMAN-MILK FAT GLOBULE ANTIGEN - IMAGING OF HUMAN-BREAST CANCER XENOGRAFTS IN NUDE-MICE
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[26] LOCALIZATION OF HUMAN-BREAST TUMORS GRAFTED IN NUDE-MICE WITH A MONOCLONAL-ANTIBODY DIRECTED AGAINST A DEFINED CELL-SURFACE ANTIGEN OF HUMAN MAMMARY EPITHELIAL-CELLS
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[27] ANTITUMOR-ACTIVITY AND PHARMACOKINETICS OF A MORPHOLINO-ANTHRACYCLINE DERIVATIVE (KRN8602) AGAINST HUMAN BREAST-CARCINOMA XENOGRAFTS SERIALLY TRANSPLANTED INTO NUDE-MICE
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