ANTICANCER ACTIVITIES OF ORALLY-ADMINISTERED MENOGARIL AGAINST HUMAN STOMACH AND BREAST CANCERS IMPLANTED IN NUDE-MICE

被引：0

作者：

INABA, M ^{[1
]}

SATO, S ^{[1
]}

YAMORI, T ^{[1
]}

TASHIRO, T ^{[1
]}

OHNISHI, Y ^{[1
]}

MARUO, K ^{[1
]}

UEYAMA, Y ^{[1
]}

TSURUO, T ^{[1
]}

机构：

[1] INST EXPTL ANIM,MIYAMAE KU,KAWASAKI,KANAGAWA 211,JAPAN

来源：

ANTICANCER RESEARCH | 1992年 / 12卷 / 6B期

关键词：

MENOGARIL; ANTITUMOR EFFECTS; STOMACH CANCERS; BREAST CANCERS; NUDE MOUSE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic effects of orally administered menogaril, a semisynthetic analog of the anthracycline antibiotic nogalamycin, were studied on a panel of human stomach and breast cancer xenografts. The maximum tolerated dose (200 mg/kg) of menogaril was administered 3 times every 4 days and its growth-inhibitory effects on subcutaneously implanted tumors in nude mice were evaluated. Menogaril significantly retarded the growth of 3 out of 7 stomach cancers, SC-2, SC-9 and 4-1ST, and 3 out of 4 breast cancers, H-31, MC-2 and MX-1, with overall response rates of 43 and 75% for stomach and breast cancers, respectively. Some of these relatively responsive cancers were also treated by daily oral administration for 5 consecutive days, but the anticancer effects of the intermittent administration seemed to be better. These results suggest that menogaril may be effective against stomach and breast cancers when orally administered.

引用

页码：1953 / 1956

页数：4

共 27 条

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TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 168 (02): : 421 - 426
[13] THE GROWTH-BEHAVIOR OF HUMAN-BREAST CANCERS ON NUDE-MICE, WHICH WERE POORLY SUPPLIED WITH NICOTINAMIDE
TESSERAUX, M
TIMM, C
BASTERT, G
FORTMEYER, HP
ZEITSCHRIFT FUR VERSUCHSTIERKUNDE, 1986, 28 (1-2): : 99 - 99
[14] MECHANISMS OF COMBINED EFFECTS OF GAMMA-INTERFERON AND 5-FLUOROURACIL ON HUMAN-COLON CANCERS IMPLANTED INTO NUDE-MICE
MORIKAWA, K
FAN, D
DENKINS, YM
LEVIN, B
GUTTERMAN, JU
WALKER, SM
FIDLER, IJ
CANCER RESEARCH, 1989, 49 (04) : 799 - 805
[15] HUMAN MAMMARY EPITHELIAL ANTIGENS (HME-AGS) IN THE CIRCULATION OF NUDE-MICE IMPLANTED WITH A BREAST-TUMOR AND NON-BREAST TUMORS
SASAKI, M
PETERSON, JA
WARA, WM
CERIANI, RL
CANCER, 1981, 48 (10) : 2204 - 2210
[16] ANTITUMOR-ACTIVITY OF ME2303, A FLUORINE-CONTAINING ANTHRACYCLINE, AGAINST HUMAN-TUMORS IMPLANTED IN NUDE-MICE
TSURUO, T
SATO, S
YUSA, K
JAPANESE JOURNAL OF CANCER RESEARCH, 1989, 80 (07): : 686 - 689
[17] ANTITUMOR EFFECT OF TRIPHENYLETHYLENE DERIVATIVE (TAT-59) AGAINST HUMAN BREAST-CARCINOMA XENOGRAFTS IN NUDE-MICE
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KAWAMURA, E
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JOURNAL OF SURGICAL ONCOLOGY, 1992, 51 (04) : 254 - 258
[18] ANTITUMOR ACTIVITIES OF KW-2152, A NEW ISOQUINON AGENT, AGAINST HUMAN-TUMOR XENOGRAFTS TRANSPLANTED INTO NUDE-MICE
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NISHIYAMA, M
NIIMI, K
HIRABAYASHI, N
TOGE, T
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HATTORI, T
JAPANESE JOURNAL OF SURGERY, 1987, 17 (02): : 146 - 149
[19] COMPARISON OF ANTI-TUMOR ACTIVITIES OF NITROSOUREA DERIVATIVES AGAINST MAMMARY BREAST-CARCINOMA (MX-1) IN NUDE-MICE
INOUE, K
FUJIMOTO, S
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GANN, 1980, 71 (05): : 686 - 691
[20] THE EFFECT OF VITAMIN ANTAGONISTS AND ANTIVITAMINS ON THE GROWTH OF VITAMIN-B6 RESPONDING HUMAN-BREAST CANCERS, HETEROTRANSPLANTED INTO NUDE-MICE
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RUSE, M
BASTERT, G
FORTMEYER, HP
ZEITSCHRIFT FUR VERSUCHSTIERKUNDE, 1986, 28 (1-2): : 99 - 99

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