NEW HETEROCYCLIC-DERIVATIVES OF BENZIMIDAZOLE WITH GERMICIDAL ACTIVITY .11. EXPERIMENTAL VALIDATION OF QSAR PREDICTION ON ANTIBACTERIAL AND ANTIMYCOTIC ACTIVITY OF BENZIMIDAZOLE DERIVATIVES

In continuation of previous studies, Authors describe the synthesis of three new derivatives of 2-(5'-nitro-2'-furyl) benzimidazole, having hydroxy, methoxy or amino group at position 5. The new compounds, synthesized as suggested by a previous chemometric study, were tested in vitro against 5 Gram + and 4 Gram- strains and the mycete C. albicans. Two derivatives (R=OH, NH2) showed a good degree of antibacterial activity, especially the 5-hydroxy derivative, but they were practically inactive against the mycete; these results are in agreement with the prediction of chemometric study.