Visible-Light-Driven Three-Component Reaction of Unactivated Alkenes Enables Access to Monofluoro ?-Amino Acids

被引：0
|
作者：
Ju, Guodong [1 ]
Huang, Zhibin [1 ]
Liu, Jian [1 ]
Xu, Xu [1 ]
Deng, Zefeng [1 ]
Zhao, Yingsheng [1 ,2 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453000, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2023年
关键词：
visible-light-driven; three-component reaction; quinoxalinones; monofluoro & gamma; -amino acids; unactivated alkenes;
D O I：
10.1002/ejoc.202300596
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A strategy for the synthesis of diverse protected a-monofluoro-?-amino acid derivatives has been developed. This reaction assembles a simple enamide, quinoxalin-2(1H)-one, and diethyl 2-bromo-2-fluoromalonate through a three-component reaction driven by visible light. The advantages of this protocol include the simplicity of its operation, mild conditions, high functional group tolerance, and applicability to a wide variety of substrates. The synthesis of this fluorine-containing amino acid derivative has significant value for potential applications in medicinal chemistry and chemical biology.
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页数：6
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