THE CRYSTAL AND MOLECULAR-STRUCTURE OF THE COMPLEX OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYGUANOSINE WITH PYRIDINE

被引：10
|
作者：
VANROEY, P
CHU, CK
机构：
[1] MED FDN BUFFALO INC,BUFFALO,NY 14203
[2] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM,ATHENS,GA 30602
来源：
NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 06期
关键词：
D O I：
10.1080/07328319208018338
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of 2',3'-didehydro-2',3'-dideoxyguanosine was determined by X-ray crystallographic analysis of the complex with pyridine. The two independent nucleoside molecules have similar, commonly observed glycosyl link (chi = -102.3-degrees and -94.2-degrees) and 5'-hydroxyl (gamma = 54.0-degrees and 47.6-degrees) conformations. The five-membered rings are very planar with r.m.s. deviations from planarity of less than 0.015 angstrom. 2',3'-Didehydro-2',3'-dideoxyadenosine has a similar glycosyl link conformation but a different 5'-hydroxyl group orientation and a slightly less planar 5-membered ring.
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收藏
页码：1229 / 1239
页数：11
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