SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXY-3'-C-METHYL SUBSTITUTED NUCLEOSIDES

被引：11
|
作者：
IOANNIDIS, P
CLASSON, B
SAMUELSSON, B
KVARNSTROM, I
机构：
[1] UNIV STOCKHOLM,DEPT ORGAN CHEM,ARRHENIUS LAB,S-10691 STOCKHOLM,SWEDEN
[2] LINKOPING UNIV,DEPT CHEM,S-58183 LINKOPING,SWEDEN
来源：
NUCLEOSIDES & NUCLEOTIDES | 1993年 / 12卷 / 08期
关键词：
D O I：
10.1080/07328319308018557
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1-(2,3-Dideoxy-3-C-hydroxymethyl-beta-D-threo-pentofuranosyl)-, 1-(2,3-didehydro-2,3-dideoxy-3-C-hydroxymethyl-beta-D-glycero-pentofuranosyl)- and 1-(3-C-azidomethyl-2,3-didehydro-2,3-dideoxy-beta-D-glycero-pentofuranosyl)uracil, thymine and cytosine were synthesized and evaluated for anti-HIV activity. The synthetic strategy was based on an allylic alcohol transposition of the corresponding 3'-C-methylene-nucleoside analogues.
引用
收藏
页码：865 / 877
页数：13
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