INTERLEUKIN-8 INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE IN RAT PERITONEAL NEUTROPHILS

被引：56
|
作者：
MCCALL, TB
PALMER, RMJ
MONCADA, S
机构：
[1] Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, Langley Court
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期
关键词：
D O I：
10.1016/0006-291X(92)90800-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of interleukin(IL)-8 and leukotriene B4 (LTB4) on the induction of nitric oxide (NO) synthase in rat peritoneal neutrophils (PMN) ex vivo was studied. IL-8, but not LTB4, caused concentration-dependent inhibition of the induction of a Ca2+-independent NO synthase ex vivo. The effect of IL-8 was not attributable to the synthesis of an inhibitor of this enzyme. These findings suggest complex regulatory control of the induction of NO synthase by cytokines. © 1992.
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页码：680 / 685
页数：6
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