CHLORPROMAZINE INHIBITS BOTH THE CONSTITUTIVE NITRIC-OXIDE SYNTHASE AND THE INDUCTION OF NITRIC-OXIDE SYNTHASE AFTER LPS CHALLENGE

被引：35

作者：

PALACIOS, M ^{[1
]}

PADRON, J ^{[1
]}

GLARIA, L ^{[1
]}

ROJAS, A ^{[1
]}

DELGADO, R ^{[1
]}

KNOWLES, R ^{[1
]}

MONCADA, S ^{[1
]}

机构：

[1] WELLCOME RES LABS,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 01期

关键词：

D O I：

10.1006/bbrc.1993.2246

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of chlorpromazine on either the activity of mouse brain nitric oxide synthase or the induction of lung nitric oxide synthase in mice and rats were studied. Chlorpromazine inhibited the nitric oxide synthase activity in mouse brain cytosol. This effect could be reversed by adding an excess of calmodulin. In addition, chlorpromazine was able to inhibit the induction of lung nitric oxide synthase, in both species, after LPS administration. Furthermore, chlorpromazine also inhibited arginase activity in mouse lung cytosol. © 1993 Academic Press, Inc.

引用

页码：280 / 286

页数：7

共 50 条

[1] CLORICROMENE INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE
ZINGARELLI, B
CARNUCCIO, R
DIROSA, M
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 243 (02) : 107 - 111
[2] CONSTITUTIVE ISOFORMS OF NITRIC-OXIDE SYNTHASE
FORSTERMANN, U
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 176 - MEDI
[3] REGULATION OF NITRIC-OXIDE SYNTHASE BY NITRIC-OXIDE
RENGASAMY, A
JOHNS, RA
[J]. MOLECULAR PHARMACOLOGY, 1993, 44 (01) : 124 - 128
[4] A NOVEL PEPTIDE INHIBITS INDUCTION OF NITRIC-OXIDE SYNTHASE
CALDWELL, RW
ABOUMOHAMED, G
PAPAPETROPOULOS, A
TUTTLE, RR
[J]. FASEB JOURNAL, 1995, 9 (03): : A326 - A326
[5] INDUCTION OF NITRIC-OXIDE SYNTHASE IN ASTHMA
HAMID, Q
SPRINGALL, DR
RIVEROSMORENO, V
CHANEZ, P
HOWARTH, P
REDINGTON, A
BOUSQUET, J
GODARD, P
HOLGATE, S
POLAK, JM
[J]. LANCET, 1993, 342 (8886-7): : 1510 - 1513
[6] REGULATION OF CONSTITUTIVE NITRIC-OXIDE SYNTHASE IN ATHEROSCLEROSIS
OHARA, Y
SAYEGH, HS
NAVAS, JP
PETERSON, TE
NISHIDA, K
HUBER, AR
POLLOCK, JS
FORSTERMANN, U
HARRISON, DG
[J]. CIRCULATION, 1993, 88 (04) : 273 - 273
[7] NIFEDIPINE INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE BY BACTERIAL LIPOPOLYSACCHARIDE
SZABO, C
MITCHELL, JA
GROSS, SS
THIEMERMANN, C
VANE, JR
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1993, 265 (02): : 674 - 680
[8] FEEDBACK INHIBITION OF NITRIC-OXIDE SYNTHASE ACTIVITY BY NITRIC-OXIDE
ASSREUY, J
CUNHA, FQ
LIEW, FY
MONCADA, S
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (03) : 833 - 837
[9] NITRIC-OXIDE, NITRIC-OXIDE SYNTHASE AND SUPEROXIDE-DISMUTASE
LIU, X
MILLER, SM
SZURSZEWSKI, JH
[J]. FASEB JOURNAL, 1995, 9 (04): : A681 - A681
[10] NITRIC-OXIDE AS A MEDIATOR OF BISACODYL AND PHENOLPHTHALEIN LAXATIVE ACTION - INDUCTION OF NITRIC-OXIDE SYNTHASE
GAGINELLA, TS
MASCOLO, N
IZZO, AA
AUTORE, G
CAPASSO, F
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1994, 270 (03): : 1239 - 1245

← 1 2 3 4 5 →