2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION WITH URSODEOXYCHOLIC ACID

被引：58
|
作者：
VANDELLI, MA
SALVIOLI, G
MUCCI, A
PANINI, R
MALMUSI, L
FORNI, F
机构：
[1] UNIV MODENA, DEPT PHARMACEUT SCI, I-41100 MODENA, ITALY
[2] UNIV MODENA, CATTEDRA GERIATR & GERONTOL, I-41100 MODENA, ITALY
[3] UNIV MODENA, DEPT CHEM, I-41100 MODENA, ITALY
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 118卷 / 01期
关键词：
URSODEOXYCHOLIC ACID; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; INCLUSION COMPLEXATION; SOLUBILITY STUDY; SOLID-PHASE STUDY; DRUG DISSOLUTION;
D O I：
10.1016/0378-5173(94)00342-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The complexation in aqueous medium and in the solid phase of ursodeoxycholic acid (UDCA) with a highly soluble cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, was studied by means of solubility methods, IR and C-13-NMR spectroscopy, X-ray diffractometry and thermal analysis. UDCA inclusion took place with 1:1 stoichiometry. C-13-NMR analysis suggested that the side chain was introduced into the cyclodextrin cavity. The UDCA/cyclodextrin complex showed better dissolution properties than plain drug crystals. Therefore, the complex may be used to improve the delivery and bioavailability of ursodeoxycholic acid.
引用
收藏
页码：77 / 83
页数：7
相关论文
共 50 条
  • [31] DEXAMETHASONE 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN (HP-BETA-CD) EYE DROPS
    STEFANSSON, E
    LOFTSSON, T
    THORISDOTTIR, S
    FRIORIKSDOTTIR, H
    KRISTINSSON, JK
    GUOMUNDSSON, O
    SIGTHORSSON, T
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 2217 - 2217
  • [32] THE INFLUENCE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON DIFFUSION RATES AND TRANSDERMAL DELIVERY OF HYDROCORTISONE
    LOFTSSON, T
    FRIORIKSDOTTIR, H
    INGVARSDOTTIR, G
    JONSDOTTIR, B
    SIGUROARDOTTIR, AM
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, 20 (09) : 1699 - 1708
  • [33] 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN IN TOPICAL CARBONIC-ANHYDRASE INHIBITOR FORMULATIONS
    LOFTSSON, T
    FRITHRIKSDOTTIR, H
    THORISDOTTIR, S
    STEFANSSON, E
    SIGURTHARDOTTIR, AM
    GUTHMUNDSSON, O
    SIGTHORSSON, T
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 1 (04) : 175 - 180
  • [34] SOLUBILIZATION AND STABILIZATION OF A BENZYLPENICILLIN CHEMICAL DELIVERY SYSTEM BY 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN
    POP, E
    LOFTSSON, T
    BODOR, N
    PHARMACEUTICAL RESEARCH, 1991, 8 (08) : 1044 - 1049
  • [35] THE USE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN AS A VEHICLE FOR INTRAVENOUS ADMINISTRATION OF DEXAMETHASONE IN DOGS
    DIETZEL, K
    ESTES, KS
    BREWSTER, ME
    BODOR, NS
    DERENDORF, H
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 59 (03) : 225 - 230
  • [36] Development of venetoclax with 2-hydroxypropyl-beta-cyclodextrin inclusion complex for improved bioavailability
    Patil, Smalant Kishor
    Chary, Padakanti Sandeep
    Maddipatla, Sarvan
    Madhavi, Y., V
    Singothu, Siva
    Bhandari, Vasundhra
    Pardhi, Ekta
    Bansal, Kuldeep Kumar
    Mehra, Neelesh Kumar
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024,
  • [37] The interaction of biliar acids with 2-hydroxypropyl-beta-cyclodextrin in solution and in the solid state
    Mucci, A
    Schenetti, L
    Salvioli, G
    Ventura, P
    Vandelli, MA
    Forni, F
    JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1996, 26 (04): : 233 - 241
  • [38] USE OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN AS A SOLUBILIZING AND STABILIZING EXCIPIENT FOR PROTEIN DRUGS
    BREWSTER, ME
    HORA, MS
    SIMPKINS, JW
    BODOR, N
    PHARMACEUTICAL RESEARCH, 1991, 8 (06) : 792 - 795
  • [39] THE EFFECT OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON THE SOLUBILITY, STABILITY AND DISSOLUTION RATE OF FAMOTIDINE
    ISLAM, MS
    NARURKAR, MM
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1991, 17 (09) : 1229 - 1239
  • [40] EFFECT OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON THE OCULAR ABSORPTION OF DEXAMETHASONE AND DEXAMETHASONE ACETATE
    USAYAPANT, A
    KARARA, AH
    NARURKAR, MM
    PHARMACEUTICAL RESEARCH, 1991, 8 (12) : 1495 - 1499
12345