2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION WITH URSODEOXYCHOLIC ACID

被引：58
|
作者：
VANDELLI, MA
SALVIOLI, G
MUCCI, A
PANINI, R
MALMUSI, L
FORNI, F
机构：
[1] UNIV MODENA, DEPT PHARMACEUT SCI, I-41100 MODENA, ITALY
[2] UNIV MODENA, CATTEDRA GERIATR & GERONTOL, I-41100 MODENA, ITALY
[3] UNIV MODENA, DEPT CHEM, I-41100 MODENA, ITALY
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 118卷 / 01期
关键词：
URSODEOXYCHOLIC ACID; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; INCLUSION COMPLEXATION; SOLUBILITY STUDY; SOLID-PHASE STUDY; DRUG DISSOLUTION;
D O I：
10.1016/0378-5173(94)00342-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The complexation in aqueous medium and in the solid phase of ursodeoxycholic acid (UDCA) with a highly soluble cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, was studied by means of solubility methods, IR and C-13-NMR spectroscopy, X-ray diffractometry and thermal analysis. UDCA inclusion took place with 1:1 stoichiometry. C-13-NMR analysis suggested that the side chain was introduced into the cyclodextrin cavity. The UDCA/cyclodextrin complex showed better dissolution properties than plain drug crystals. Therefore, the complex may be used to improve the delivery and bioavailability of ursodeoxycholic acid.
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页码：77 / 83
页数：7
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